Hypothalamic Neurogenesis at the Interface of Obesity and Stress Flashcards
Why is obesity such an issue at present day??
No effective cure, yet it is an ever increasing problem
How are obesity and stress associated?
Obesity is a risk factor for stress & anxiety
Gut hormones and neuropeptides regulating appetite
also innervate the HPA axis.
Central mechanisms of eating behaviour and the overlap
between mental health and obesity is obvious but has
never been fully explored
Maternal obesity and development of offspring
Altered epigenetic changes in the fetal brain - inlcuding DNA methylation, miRNAs, and histone
modification
→ may lead to increased predisposition to depression, anxiety and ?? ASD and ADHD
Lateral Hypothalamus, also known as …
the feeding centre - stimulatin of this region often causes hyperphagia & obesity, while lesions induce anorexia
Ventromedial Hypothalamus, also known as …
Satiety centre - lesions cause hyperphagia
site of convergence for neuroendocrine signals?
Arcuate nucleus, which is comprised of a diverse population of peptidergic neurons that orchestrate behavioral responses to food in times of energy deficit
Major site of neurogenesis
Hippocampus
Tancytes
progenitor stem cell population of the hypothalamus, NB as they express transcription factors depending on hormonal, nutritional and mitogenic signals
Neurogenesis is ___ in both obesity and depressive disorders
dysfunctional
