Hypopituitarism Flashcards
What is hypopituitarism
This refers to the reduced secretion of pituitary hormones, which ca result from disease of either the pituitary gland or the hypothalamus
What are the majority of hypopituitarism caused by
pituitary tumours or their treatment
Mutations in what gene are the most common cause of both familial and sporadic congenital combined pituitary hormone deficiency
PROP 1
What do mutations in the PROP 1 gene result in
deficiencies in GH, prolactin, TSH, LH and FSH
What do mutations in TPIT cause
adrenocorticotrophin hormone (ACTH) deficiency
What can mutations in TPIT cause if not detected early
Neonatal death
What are the clinical presentations of GH deficiency
Fatigue
impaired psychological well being
reduced energy, muscle strength and exercise capacity
increased abdominal adiposity (fat mass)
What does LH / FSH deficiency result in
secondary hypogonadism
What are symptoms of secondary hypogonadism in males
Reduced libido oligospermia infertility loss of body hair fine premolar wrinkles flushes osteoporosis
What are symptoms of secondary hypogonadism in females
oligomennorrhoea amenorrhoea infertility dyspareunia breast atrophy hot flushes osteoporosis
What does ACTH deficiency result in
secondary adrenal insuffieicney
What are symptoms of ACTH deficiency
fatigue weakness nausea vomiting weight loss hypoglycaemia loss of pubic and axillary hair in females
What does TSH deficiency result in
secondary hypothyroidism
What are symptoms of TSH deficiency
fatigue apathy muscle weakness cold intolerance constipation weight gain dry skin
What is the only known presentation of prolactin deficiency
inability to lactate after delivery
