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BRS 2* > Hypopituitarism > Flashcards

Hypopituitarism Flashcards

1
Q

Anterior pituitary hormone pathway

A

Hypothalamus–>
stalk–>
hypophyseal portal veins–>
anterior pituitary

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2
Q

GH production pathway

A

GHRH/somatosatin–>
somatotrophs–>
GH–>
growth (somatostatin/IGF-1)

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3
Q

Prolactin production pathway

A

Dopamine–>
Lactotrophs–>
Prolactin–>
lactation

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4
Q

TSH production pathway

A

TRH–>
Thyrotrophs–>
TSH–>
T3/T4

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5
Q

LH/FSH production pathway

A

GRH–>
Gonadotrophs–>
LH/FSH–>
Oestrogen/progesterone/testosterone

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6
Q

ACTH production pathway

A

CRH–>
Corticotrophs–>
ACTH–>
Cortisol

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7
Q

T3/T4 during primary hypothyroidism

A

Low

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8
Q

TSH during primary hypothyroidism

A

Increases

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9
Q

T3/T4 during secondary hypothyroidism

A

Decreases

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10
Q

TSH during secondary hypothyroidism

A

Low

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11
Q

Cortisol during primary hypoadrenalism

A

Low

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12
Q

ACTH during primary hypoadrenalism

A

Increases

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13
Q

Cortisol during secondary hypoadrenalism

A

Decreases

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14
Q

ACTH during secondary hypoadrenalism

A

Low

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15
Q

Testosterone/oestrogen during primary hypogonadism

A

Low

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16
Q

LH/FSH during primary hypogonadism

A

Increases

17
Q

Testosterone/oestrogen during secondary hypogonadism

A

Decreases

18
Q

LH/FSH during secondary hypogonadism

A

Low

19
Q

Congenital cause of hypopituitarism (rare)

A

Mutation of transcription factors (PROP1)

  • GH deficiency + at least one more AP hormone
  • Short stature
  • Hypoplastic AP on MRI
20
Q

Causes of primary hypogonadism

A

Mumps (testes), chemo (ovaries)

21
Q

Acquired causes of hypopituitarism (8)

A
  • Tumours (adenoma, metastases, cysts)
  • Radiation (hypothalamic/pituitary)
  • Infection (meningitis)
  • Traumatic brain injury
  • Pituitary surgery
  • Hypophysitis
  • Pituitary apoplexy
  • Peri-partum infarction
22
Q

Total loss of anterior + posterior pituitary function is called

A

Panhypopituitarism

hypophysitis/surgery

BRS 2* (7 decks)

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