Hypogonadism

Question 1

What are some causes of primary hypogonadism?

Answer 1

Chromosomal abnormalities - ie Klinefelter syndrome, males with more than 1 X chromosom and XX males.

2. Congenital Anorchia
3. Chemotherapy and radiation induced hypogonadism
4. Sertoli cell only syndrome Del Castillo syndrome)
5. Testicular dysgenesis syndrome.

Question 2

How do you diagnose primary hypogonadism?

Answer 2

Low testosterone. No rise after HCG.

Bone age may help (with constitutional delay)