Hypoglycemic Drugs

Question 1

Name the classes of drugs

Answer 1

Metformins
Sulfoneureas
Alpha glucosidase Inhibitor
Thiazolidinodiones
Dpp-4 inhibtors
Exentide

Question 2

Functions of metformins

Answer 2

Sensitivity of insulin increase
Inc pheriperal glucose uptake
Dec glucos uptake from gut
Inhibit hepatic gluconeogenesis

Question 3

Which drugs are nsulin secreting

Answer 3

Sulfonureas
Dpp-4
Exentide

Question 4

Name the drugs of sulphonylureas
And safest for pregnancy

Answer 4

1st gen: Tolbutamide,Chlorpropamide
2nd; glipizide, glibenclamide

Question 5

Advantage and disadv of metformins

Answer 5

Adv: no hypoglycemia and help weighloss
Dis: lactic acidosis not recomded in pt with 150micromol/l above cretinine

Question 6

names of alpha glucosidase inhibitor and function

Answer 6

Acarbose and Miglitol
Inhibit absoption of glucose from gut can cause diarrhea

Question 7

Name thiazelidinediones
Functions and disadvantaes

Answer 7

Roziglitazone and pioglitazone
Inc insulin sen in skletal mucle by activtion Peroxisome proliferator activated receptor-gamma
Wiegh gain, hypertoxicity, risk of mi(rosi not pio), bone frracture, fluid retention

Question 8

Names of dpp-4 inhibitor and Exentide
Funcs

Answer 8

Sitagliptin and vildagliptn
Dpp4 is a hormone which degrade glp1 and glp1 is insulin secertory hormone and dpp4 inhibit which result in production of glp1
Exentide s glp agonist