Hyperthyroidism

Question 1

Drugs that block the convertion of T4 to T3:

Answer 1

1. Propylthiouracil (PTU)
2. propranolol(at least 160mg/day)
3. Corticosteroids

Question 2

When giving beta blockers in pt with thyroid strom:

Answer 2

1. In normal pt, if tachycardia, compromise cardiac output, leading to APO, to give beta blocker is logical.
2. However, for pt with cardiomyopathy, adrenergic drive is essential to keep thw heart going. Beta blocker will kill the pt. (To used the short T1/2 , short acting beta blockers)