Hypertension Drugs Flashcards
What are the types of first line hypertension drugs?
- ACE-inhibitors (-pril)
- Angiotensin Receptor Blockers (-sartan)
- Beta-Blockers (-olol)
- Calcium Channel Blockers (-dipine + verapamil)
- Diuretics (Thiazides) (indapamide, hydrochlorothiazide)
Write out the two flowcharts of control of blood pressure
Compare to slides
What is the mechanism of action of ACE inhibitors?
- Inhibits ACE enzymes so less Ang II
- Blocks the inactivation of bradykinin = bradykinin increases, leads to production of NO, PG, ultimately causing vasodilation
What are the clinical uses of ACE inhibitors?
- Hypertension
- Cardiac Failure
- Following MI
- Renal Insufficiency
What are the adverse effects of ACE inhibitors?
- Severe Hypotension
- Acute Renal Failure
- Hyperkalemia
- Angioedema (bradykinin and substance P induced “inflammatory-like” responses) & Dry Cough (bradykinin & PG increased sensitivity of bradykinin-dependent airway sensory nerve fibres)
- NO in pregnancy
What is the mechanism of action of AT1 blockers?
Block action of angiotensin 2 by preventing it from binding to AT1 receptor
What are the adverse effects of AT1 blockers?
- Dry Cough (less than ACE Inhibitors)
- NO to pregnancy
What is the mechanism of action of beta blockers?
- Blocking beta adrenergic receptor prevents signalling to activate adenylate cyclase
- ATP not converted to cAMP
- PKA not activated
- Calcium channel not opened
- No calcium, no CICR, no Ca-calmodulin complex
- MLCK not activated
- Myosin LC not phosphorylated to active form
- Reduced contraction of heart
What are the main types of beta blockers?
Non-Selective:
1. Propanolol
2. Pindolol
3. Carvedilol
Cardioselective:
1. Atenolol
2. Bisprolol
3. Metoprolol
Mixed:
1. Nebivolol
- beta 1 selective in low dose
- non-selective in high dose
- vasodilatory effects via NO release
Which beta blockers can also be used to treat heart failure?
- Carvedilol
- Bisoprolol
- Metoprolol
- Nebivolol
What are the clinical uses of beta blockers?
- Hypertension
- Cardiac Failure
- Following MI
- Abnormal Heart Rhythm
- Anxiety Disorders
What are the adverse effects of beta blockers?
Hypotension
Bradycardia
AV nodal block
Reduced Exercise Capacity
Bronchoconstriction
CNS: Vivid Dreams, Clinical Depression
What is the mechanism of action of thiazides?
- Inhibit NaCl reabsorption at DCT by blocking the transporter
- Enhance Ca reabsorption in DCT
What are the clinical uses of thiazides?
- HTN
- Heart Failure
- Nephroloithiasis due to idiopathic hypercalcemia
- Nephrogenic Diabetes Insipidus
What are the adverse effects of thiazides?
- Hypokalemic Metabolic Acidosis
- Hyponatremia
- Hyperurecemia
- Hyperglycemia
- Hyperlipidemia
- Hypercalcemia