Hypertension Flashcards
Drugs
Angiotensin converting enzyme inhibitors Examples: Ramipril Lisinopril Perindopril
Calcium channel blockers
Examples:
Amlodipine
Felodipine
Thiazide or thiazide-like diuretics
Examples:
Bendro-flumethiazide (thiazide)
Indapamide (thiazide-like)
Angiotensin receptor blockers Examples: Losartan Irbesartan Candesartan
Angiotensin converting enzyme inhibitors action
Inhibit the angiotensin converting enzyme.
Prevent the conversion of angiotensin I to angiotensin II by ACE.
ACEi target
ACE
ACEi side effects
Cough
Hypotension
Hyperkalaemia (care with K+ supplements or K+-sparing diuretics)
Foetal Injury (AVOID IN PREGNANT WOMEN)
Renal failure (in patients with renal artery stenosis)-
Urticaria/Angioedema
ACEi other
Most ACE inhibitors (not lisinopril) are pro-drugs. They require hepatic activation to generate the active metabolites required for therapeutic effects.
eGFR and serum potassium must be regularly monitored when prescribing ACE inhibitors.
In 2020, ramipril was the 7th, lisinopril the 42nd and perindopril the 51st most commonly prescribed drugs in the West London area
Calcium channel blocker action
Block L-type calcium channels – predominantly on vascular smooth muscle. This results in a decrease in calcium influx, with downstream inhibition of myosin light chain kinase and prevention of cross-bridge formation. The resultant vasodilation reduces peripheral resistance.
Calcium channel blocker target
L-type calcium channel
Calcium channel blocker side effects
Ankle oedema
Constipation
Palpitations
Flushing/Headaches
Calcium channel blocker other
Dihydropyridine type calcium channel blockers demonstrate a higher degree of vascular selectivity
In 2020, amlodipine was the 2nd and felodipine the 98th most commonly prescribed drugs in the West London area
Thiazide action
They block the Na+, Cl- co-transporter in the early DCT.
Therefore Na+ and Cl- reabsorption is inhibited.
As a result the osmolarity of the tubular fluid increases, decreasing the osmotic gradient for water reabsorption in the collecting duct.
Thiazide target
Sodium/chloride cotransporter
Thiazide side effects
Hypokalemia
Hyponatremia.
Metabolic alkalosis (increased hydrogen ion excretion)
Hypercalcemia.
Hyperglycemia (hyperpolarised pancreatic beta cells).
Hyperuricemia.
Thiazide other
Thiazide and thiazide-like diuretics both lose their diuretic effects within 1-2 weeks of treatment. Continuing anti-hypertensive action appears to be due to vasodilating properties (these are more pronounced for the thiazide-like diuretics)
In 2020, bendro-flumethiazide was the 38th and indapamide the 46th most commonly prescribed drugs in the West London area
Angiotensin receptor blocker action
These agents act as insurmountable (i.e. non-competitive) antagonists at AT1 receptor (found on kidneys and on the vasculature)
Angiotensin receptor blocker target
Angiotensin receptor