Hypertension Flashcards

1
Q

What are the goals of the recommendations for treating hypertension?

A

Improvement of cardiovascular health and quality of life through the prevention and treatment of risk factors.

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2
Q

Causes of Hypertension

A

More prevalent in African American men and women.
Earlier age in European Americans or Latinos.
Tends to increase with age.
More common with genetic predisposition.
Lifestyle- sedentary, stressful situations.
High sodium intake (increases peripheral vascular resistance, thus increasing BP)

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3
Q

Secondary Hypertension

A

Reversible causes (Cardiac, renal, endocrine, or medications causing vasoconstriction)

Secondary is seen <30 and >50 years of age. BP is >180/110 and significant target organ damage, hemorrhages are seen, and exudates on the funduscopic exam, renal insufficiency, LVH, accelerated or malignant therapy.

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4
Q

Causes of secondary hypertension

A
Obesity
OSA
Renovascular disease
Chronic corticosteroid therapy
Cushing's syndrome
Primary aldosteronism
Pheochromocytoma
Coarctation of the aorta
Hyperthyroid disease
Parathyroid disease
Excessive ETOH
Drug induced: NSAIDs, licorice, oral contraceptives, erythropoietin, cocaine, amphetamines, corticosteroids, cyclosporine, herbal ephedra, smoking, chewing tobacco.
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5
Q

White Coat Hypertension

A

Transient elevation in BP in clinical setting r/t anxiety.

Important to monitor with an appropriate sized cuff. Too small, too high.

Patients should have ambulatory BP monitoring, 24 hour recording during normal daily activities that can be reviewed by the clinical. Pt may monitor over several weeks with reliable equipment and follow up with log.

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6
Q

Masked Hypertension

A

HTN that is present during routine daily life and absent in clinical setting. Important to perform ambulatory blood pressure monitoring.

Risk factors

  • Smoking
  • Alcohol use
  • Sedentary lifestyle
  • Work, physiological stressors

These patients are at higher risk for cardiovascular event, mortality and morbidity d/t missed treatment.

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7
Q

Malignant Hypertension

A

Diagnosed when patients present with severely elevated BP 180/110 and acute target organ damage.

AKA hypertensive emergency or hypertensive crisis.

If not treated with immediate parenteral antihypertensive therapy may prove fatal. Treated/reduced over the course of hours with oral and or IV medications.

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8
Q

Hypertensive Urgency

A

A significant elevation of blood pressure on it’s own.

Treated with oral medications over a 24-48 hour period to achieve stabilization.

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9
Q

Acute Target Organ Damage Evidence

A
Cerebrovascular events
Papilledema, hemorrhages, or exudates on funduscopic exam. 
Acute MI or infarction.
CHF
Pulmonary edema
Aortic dissection
Acute renal failure or dysfunction evidenced by hematuria, proteinuria, or elevated serum creatinine.
States of catecholamine excess
Epistaxis
Preeclampsia or eclampsia
Change in mental status or neurological deficits on physical examination
Dementia
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10
Q

When taking a history focused on hypertension risk factors include?

A
Age
Gender
Menopausal status
Diet
Physical activity
Alcohol/caffeine use
Smoking
Dyslipidemia
DM
FMH CAD
Current medications-OTC cold meds, NSAIDs, sympathomimetics
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11
Q

Hypertension: Physical Exam should include

A
Fundoscopic exam
Palpation of the chest for PMI
Ausculation of heart
Abdominal assessment: check for masses, bruits, widened aortic diameter, enlarged kidneys. 
Palpation of peripheral pulses
Neurological exam
Fundoscopic exam
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12
Q

Hypertension: Objective Data to Collect

A

EKG
U/A
Serum Creatinine
Chest x-ray
CT head to r/o CVA (severe HA or Mental status changes)
BP in both arms, pt seated with both feet flat. Arm at heart level. Appropriate sized cuff. Two minutes apart.

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13
Q

Identifiable Causes of Hypertension

A
OSA
Drug induced
Chronic kidney disease
Primary aldosteronism
Renovascular disease
Chronic steroid therapy and Cushing's syndrome
Pheochromocytoma
Coarctation of aorta
Thyroid or parathyroid disease
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14
Q

Normal BP

A

SBP <120
DBP <80
Encourage lifestyle modifications

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15
Q

Prehypertension

A

SBP 120-139
DBP 80-90
Lifestyle modifications
No drug therapy indicated without compelling indication.

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16
Q

Stage 1 Hypertension

A

SBP 140-159
DBP 90-99
Lifestyle modifications

W/O compelling indication: Start thiazide type diuretics for most. ACEI, ARB, BB, CCB or combination.

17
Q

Stage II Hypertension

A

SBP 160 or <
DBP 100 or <
Lifestyle modifications.
W/O compelling indication: Two-drug combination for most (usually thiazide-type diuretic and ACEI or ARB or BB or CCB)

18
Q

Renin Inhibitors

A

Renin is an enzyme proceduced by kidneys that starts a chain reaction of chemical steps that increase blood pressure.

Ex) Aliskiren (Tekturna) slows down production of renin, reducing the ability to begin this process.
Do not take with ACE inhibitors or angiotensive II receptor blockers if you have diabetes or kidney disease d/t r/o complication such as stroke.

19
Q

Lifestyle Modications

A
DASH- dietary approach to stopping HTN, low NA, high K (low K = vasoconstriction)
Exercise
Weight Loss
Moderate ETOH
Not always successful as Lone Ranger
Can drop SBP 20 points
20
Q

Hypertension Follow Up

A

Serum potassium and creatinine 1-2 a year when stable.
After BP is stable, f/u visits 3-6 month intervals.

Optimal BP with treatment S<140 D<90
DM, Renal disease S <130 over D<80

21
Q

Diagnostic Studies at F/U

A

Echo- look at EF, valves, pulmonary HTN
EKG- LVH, MI
Blood work- TSH, CBC, lipids, renal function, DM

22
Q

Thiazide Diuretics

A

Thiazide diuretics are a type of diuretic (a drug that increases urine flow). They act directly on the kidneys and promote diuresis (urine flow) by inhibiting the sodium/chloride cotransporter located in the distal convoluted tubule of a nephron (the functional unit of a kidney).

Check serum potassium levels.

chlorthalidone
hydrochlorothiazide
methyclothiazide

Worsen gout, worsen lipids 10%, worsen glucose

23
Q

Calcium Channel Blockers

A
"-pine"
Amlodipine
Diltiazem
Norvasc
Verapamil

Not synergistic with HCTZ
DHP and non DHP- doesn’t hurt pulse

24
Q

ACE Inhibitors

A
"-pril"
Captopril
Enalapril
Lisinopril
Rampril

Hold onto potassium
Work in kidney- renal failure
Angioedema- frequent, any dose
Cough

25
Q

Angiotensin Receptor Blockers

A
"-sartan"
Candesartan
Irbesartan
Losartan
Valsartan

ARB and ACE not used together.
Do not get much more BP reduction

26
Q

Beta Blocker

A
"-olol"
Labetalol
Atenolol
Metoprolol
Propanolol

Works in kidney
Bradycardia
COPD- don’t want to block beta receptors. Can use cardioselective beta-blockers
Glaucoma- ophthalmic beta-blocker… synergistic
Mask hypoglycemia
Post MI