Hypersensitivity Mediators (more!)

Question 1

Associated with Th2 cells and lead to Ig class switching in B cells to produce IgE

Answer 1

IL-4 & IL-13

Question 2

Promote survival and activation of eosinophils

Answer 2

IL-3, IL-5 & GM-CSF

Question 3

What produces IL-5? What is IL-5’s function?

Answer 3

Th2 lymphocytes
Prolongs survival of eosinophils
Enhances leukotriene production and cytotoxicity for parasites

Question 4

Chemotactic for T cells and Eosinophils

Answer 4

RANTES (CCL5) and Eotaxin (CCL11)

CCR3 receptor on eosinophils for Eotaxin

Question 5

Early phase mediator, released by mast cells and basophils ONLY, short half life, toxic to parasites, increases vascular permeability, causes smooth muscle contraction

Answer 5

Histamine

Question 6

Lipid mediators, lead to eosinophil migration, smooth muscle cell contraction, vascular permeability and mucus hyper secretion

Answer 6

Leukotrienes: LTC4, LTD4, LTE4

Question 7

Released solely from mast cells – preformed stores
Two forms: alpha (constituitive) and beta (mast cells)
Remains identifiable in serum for up to 4 hours
Best marker of mast cell activation
Leads to remodeling of connective tissue matrix

Answer 7

Tryptase

Question 8

Late phase response
Mast cell activation
Helminthotoxic

Answer 8

MBP (major basic protein)

Question 9

Late response

Neurotoxin

Answer 9

EDN (eosinophil derived neurotoxin)

Question 10

Late phase response

Same as MBP plus neurotoxic

Answer 10

ECP (eosinophil cationic protein)

Question 11

Early phase mediators for Type I

Answer 11

Histamine
Tryptase
PGD2
Thromboxane
LTC4

Question 12

Late phase mediators for Type I

Answer 12

LTB4, LTC4
PGD2, PGE2, PGF2a
Kinins
Histamine
GM-CSF, IL-5
ECP, MBP, EPO