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Immunology > Hypersensitivity Disorders > Flashcards

Hypersensitivity Disorders Flashcards

1
Q

Immediate hypersensitivity type I mechanism

A

Mast cells and their mediators (vasoactive amines, lipid mediators, and cytokines)

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2
Q

Antibody mediated hypersensitivity type II mechanism

A

Opsonization and phagocytosis of cells

Complement and Fc receptor mediated recruitment and activation of leukocytes. Abnormalities in cellular functions

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3
Q

Immune complex mediated type III mechanism

A

Complement and Fc receptor mediated recruitment and activation of leukocytes

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4
Q

T cell mediated type IV mechanism

A

Recruitment and activation of leukocytes, direct target cell killing, cytokine mediated inflammation

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5
Q

Immediate hypersensitivity type I immune component

A

IgE antibody

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6
Q

Antibody mediated type II immune component

A

IgM, IgG antibodies against cell surface or extracellular matrix antigens

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7
Q

Immune complex mediated type III immune component

A

Immune complexes of circulating antigens and IgM or IgG antibodies

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8
Q

T cell mediated type IV immune component

A

CD4+ and CD8+ T cells

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9
Q

Autoimmune hemolytic anemia mechanism

A

Opsonization and phagocytosis of erythrocytes, complement mediated lysis

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10
Q

Autoimmune thrombocytopenia purpura mechanism

A

Opsonization and phagocytosis of platelets

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11
Q

Pemphigus vulgaris mechanism

A

Antibody mediated activation of proteases, disruption of intercellular adhesions

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12
Q

Vasculitis caused by ANCA mechanism

A

Neutrophil degranulation and inflammation

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13
Q

Goodpasture’s syndrome mechanism

A

Complement and Fc receptor mediated inflammation

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14
Q

Acute rheumatic fever mechanism

A

Inflammation, macrophage activation

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15
Q

Myasthenia gravis mechanism

A

Antibody inhibits acetylcholine binding, downmodulates receptors

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16
Q

Graves’ disease mechanism

A

Antibody mediated stimulation of TSH receptors

17
Q

Insulin resistant diabetes mechanism

A

Antibody inhibits binding of insulin

18
Q

Pernicious anemia mechanism

A

Neutralization of intrinsic factor

Immunology (4 decks)

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