Hypersensitivity Flashcards
Immediate hypersensitivity is also known as ?
Type I hypersensitivity
Pathologic reaction that is caused by the release of mediators from mast cells?
Immediate type 1 hypersensitivity
Immediate hypersensitivity relies upon the production of which immunoglobin antibody and what does it bind to?
IgE; mast cells
Diseases that are caused by antibodies other than IgE that are directed against cell or tissue antigens
Type II hypersensitivity; antibody mediated
Antibodies against soluble antigens may form complexes with the antigens, and the immune complexes may deposit blood vessels in various tissues, causing
inflammation and tissue injury
Antibodies against soluble antigens may form complexes with the antigens, and the immune complexes may deposit blood vessels in various tissues, causing inflammation and tissue injury. These represent what type of hypersensitivity?
Type III; immune complex disease
What diseases result from the reactions of T lymphocytes, often against self antigens in tissues?
T- cell mediated diseases; Type IV hypersensitivity
What are some mechanisms of tissure injury and disease for immediate hypersensitivity?
mast cell derived mediators- vasoactive, amines, lipid mediators, cytokines
cytokine mediated inflammation- eosinophils, neutrophils, lymphocytes
What are some mechanisms of tissure injury and disease for antibody mediated hypersensitivity?
complement and Fc receptor recruitment and activation of leukocytes ( neutrophils, macrophages
opsonization and phagocyosis of cells
abnormalities in cellular function
What are some mechanisms of tissure injury and disease for immune- complex mediated hypersensitivity?
complement and Fc receptor mediated recruitment and activation of leukopcytes, and tissue damage secondary to impaired blood flow
What are some mechanisms of tissure injury and disease for T-cell mediated hypersensitivity?
- macrophage actiavtion, cytokine- mediated inflammation
2. direct target cell lysis, cytokine- mediated inflammation
Pathologic immune mechanisms for Type I hypersensitivity?
Th2 cells, IgE antibody, mast cells, eosinophils
Pathologic immune mechanisms for Type II hypersensitivity?
IgM, IgG antibodies against cell surface or extracellular matrix antigens
Pathologic immune mechanisms for Type III hypersensitivity?
Immune complexes of circulating antigens and IgG or IgM antibodies deposited in vascular basement membrane
Pathologic immune mechanisms for Type IV hypersensitivity?
CD4+ and CD8+ T cells
