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Diseases- Ari > Hypersensitivities > Flashcards

Hypersensitivities Flashcards

1
Q

Autoimmune Hemolytic Anemia

A

Type II

Lysis of RBCs –> hemolysis and anemia

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2
Q

Autoimmune (idiopathic) thrombocytopenia purpura

A

Type II

Platelet membrane proteins are targeted –> opsonization and phagocytosis of platelets –> lysis –> bleeding

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3
Q

Pemphigus Vulgaris

A

Type II

Target- proteins in intercellular junctions (desmosomes)

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4
Q

Goodpasture’s Syndrome is associated with what symptoms?

A

Type II

Nephritis, lung hemorrhages

Target is noncollagenous protein in basement membrane of kidney glomeruli and lung alveoli

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5
Q

Acute Rheumatic Fever

A

Type II

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6
Q

What disease has Ab cross reaction with myocardial antigen?

A

Acute Rheumatic Fever

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7
Q

Myasthenia Gravis

A

Type II

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8
Q

What disease is associated with Acetylcholine receptor as it’s target?

A

Myasthenia Gravis

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9
Q

What disease causes hyperthyroidism?

A

Graves’ Disease

Type II

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10
Q

What is the MOA of Graves’ disease?

A

Ab binds thyroid receptor and causing over release of thyroid hormone

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11
Q

Pernicious Anemia

A

Type II

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12
Q

SLE is what hypersensitivity?

A

III

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13
Q

What is the target for SLE?

A

anti-nuclear Ab towards components of nucleus including DNA, nucleoproteins, etc.

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14
Q

Serum sickness

A

Type III

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15
Q

Type I diabetes mellitus

A

Type IV

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16
Q

MOA of Type I diabetes?

A

T-cells against B-cells that secrete insulin in islets of Langerhans

17
Q

Rheumatoid Arthritis

A

Type IV

18
Q

Multiple Sclerosis

A

Type IV

19
Q

Ab against mylein proteins is associated with…

A

MS

20
Q

MOA of MS is…

A

demyelination of neurons in the CNS –> sensory and motor dysfunction

21
Q

Contact Sensitivty with poison ivy is

A

Type IV

22
Q

PPD test for TB is

A

Type IV

23
Q

Superantigen mediated disease MOA is…

A

activation of many T-cells of different effector function causing a cytokine storm

24
Q

Wheal and flare and swelling are seen in what hypersensitivity

A

Type I

25
Q

Anaphylactic shock, edema, diarrhea, vomiting, rhinitis, polyps are pathology of which hypersensitivity?

A

Type I

26
Q

Chronic rejection is delayed type reaction which makes it what hypersensitivity?

A

Type IV

27
Q

Ab against nucleus contents leads to which Type III hypersensitivity?

A

SLE

28
Q

What autoimmune disease is associated with IgG and IgM antibodies against the individuals own IgG Fc region?

A

Rheumatoid Arthritis

29
Q

Sjogren’s Syndrome is when B- and T-cells attack…

A

Exocrine glands all around the body

Diseases- Ari (4 decks)

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