Hypersensitivities Flashcards
Autoimmune Hemolytic Anemia
Type II
Lysis of RBCs –> hemolysis and anemia
Autoimmune (idiopathic) thrombocytopenia purpura
Type II
Platelet membrane proteins are targeted –> opsonization and phagocytosis of platelets –> lysis –> bleeding
Pemphigus Vulgaris
Type II
Target- proteins in intercellular junctions (desmosomes)
Goodpasture’s Syndrome is associated with what symptoms?
Type II
Nephritis, lung hemorrhages
Target is noncollagenous protein in basement membrane of kidney glomeruli and lung alveoli
Acute Rheumatic Fever
Type II
What disease has Ab cross reaction with myocardial antigen?
Acute Rheumatic Fever
Myasthenia Gravis
Type II
What disease is associated with Acetylcholine receptor as it’s target?
Myasthenia Gravis
What disease causes hyperthyroidism?
Graves’ Disease
Type II
What is the MOA of Graves’ disease?
Ab binds thyroid receptor and causing over release of thyroid hormone
Pernicious Anemia
Type II
SLE is what hypersensitivity?
III
What is the target for SLE?
anti-nuclear Ab towards components of nucleus including DNA, nucleoproteins, etc.
Serum sickness
Type III
Type I diabetes mellitus
Type IV
MOA of Type I diabetes?
T-cells against B-cells that secrete insulin in islets of Langerhans
Rheumatoid Arthritis
Type IV
Multiple Sclerosis
Type IV
Ab against mylein proteins is associated with…
MS
MOA of MS is…
demyelination of neurons in the CNS –> sensory and motor dysfunction
Contact Sensitivty with poison ivy is
Type IV
PPD test for TB is
Type IV
Superantigen mediated disease MOA is…
activation of many T-cells of different effector function causing a cytokine storm
Wheal and flare and swelling are seen in what hypersensitivity
Type I
Anaphylactic shock, edema, diarrhea, vomiting, rhinitis, polyps are pathology of which hypersensitivity?
Type I
Chronic rejection is delayed type reaction which makes it what hypersensitivity?
Type IV
Ab against nucleus contents leads to which Type III hypersensitivity?
SLE
What autoimmune disease is associated with IgG and IgM antibodies against the individuals own IgG Fc region?
Rheumatoid Arthritis
Sjogren’s Syndrome is when B- and T-cells attack…
Exocrine glands all around the body
