Hyperlipidemia categories

Question 1

Fredrickson Genetic Hyperlipidemia I

Answer 1

I
Severe hypertriglyceridemia
Childhood with trigs > 2000

Excess:
Chylomicron

Primary Defect:
LPL or apo C2 or C3

Very rare

main abnormal lipid:
TG > 2000

Question 2

Fredrickson Genetic Hyperlipidemia IIa

Answer 2

IIa
Familial Hypercholesterolemia
CAD less than age 60

excess: LDL

primary defect:
LDL-R

frequency:
common

main abnormal lipid:
TC>275, LDL-C > 190

Question 3

Fredrickson Genetic Hyperlipidemia IIb

Answer 3

IIb
Familial Combined Hyperlipidemia or with Metabolic Syndrome (dyslipidemia slide)
CAD risk 2X normal despite borderline lipid numbers

Excess:
LDL, VLDL

Primary Defect:
Overproduction of apoB100

Common

main abnormal lipid:
LDL 100, trigs 200 – 500, HDL

Question 4

Fredrickson Genetic Hyperlipidemia III

Answer 4

III
Dysbetalipoproteinemia
Premature CAD

Excess:
VLDL, IDL

Primary Defect:
Apo E2 + overproduction

Rare

main abnormal lipid:
TC and trigs both 200 to 500

Question 5

Fredrickson Genetic Hyperlipidemia IV

Answer 5

IV
Hypertriglyceridemia
Pancreatitis

Excess:
VLDL

Primary Defect:
LPL or apoC3

Common

main abnormal lipid:
Trigs 500 - 1000

Question 6

Fredrickson Genetic Hyperlipidemia V

Answer 6

V
Hypertriglyceridemia
Pancreatitis, usually diabetic

Excess:
VLDL, chylo

Primary Defect:
LPL or apoC3

Uncommon

main abnormal lipid:
Trigs > 1000