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Therapeutics > Hyperlipidemia > Flashcards

Hyperlipidemia Flashcards

1
Q

Lescol Generic

A

Fluvastatin

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2
Q

Livalo Generic

A

Pitavastatin

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3
Q

Mevacor/Altoprev Generic

A

Lovastatin

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4
Q

Pravachol Generic

A

Pravastatin

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5
Q

Zocor Generic

A

Simvastatin

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6
Q

Lipitor Generic

A

Atorvastatin

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7
Q

Crestor Generic

A

Rosuvastatin

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8
Q

Fluvastatin Dose

A

Low: 20-40 mg/day
Moderate: 80 mg/day

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9
Q

Pitavastatin Dose

A

Low: 1 mg/day
Moderate: 2-4 mg/day

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10
Q

Lovastatin Dose

A

Low: 20 mg/day
Moderate: 40 mg/day

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11
Q

Pravastatin Dose

A

Low: 10-20 mg/day
Moderate: 40-80mg/day

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12
Q

Simvastatin Dose

A

Low: 10 mg/day
Moderate: 20-40mg/day

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13
Q

Atorvastatin Dose

A

Moderate: 10-20mg/day
High: 40-80 mg/day

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14
Q

Rosuvastatin Dose

A

Moderate: 5-10mg/day
High: 20-40 mg/day

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15
Q

Statin Side Effects

A 
Myopathy
Rhabdomyolysis
Muscle pain
Liver enzyme abnormalities
HA
Dyspepsia
Abdominal pain
Nausea
Upper respiratory infection
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16
Q

Statin Monitoring

A

FLP: Baseline, 4-12 wks after starting, then 3-12 months
CK: Baseline, if muscle symptoms
LFT: Baseline, if suspected liver damage
Muscle pain symptoms

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17
Q

Zetia Generic

A

Ezetimibe

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18
Q

Ezetimibe Dose

A

10 mg daily

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19
Q

Ezetimibe Side Effects

A

Arthralgia
Upper respiratory tract infection
Diarrhea

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20
Q

Ezetimibe Monitoring

A

FLP baseline

LFTs

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21
Q

Praluent Generic

A

Alirocumab

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22
Q

Alirocumab Dose

A

75 mcg SQ q 2 weeks

150 mcg q 2 weeks post 4-8 weeks

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23
Q

Alirocumab Side Effects

A 
GI side effects
↑ LFT
Injection site reaction
Myalgia
Influenza
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24
Q

Alirocumab Monitoring

A

LDL-C within 4-8 weeks of starting or changing dose

Hypersensitivity

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25
Q

Repatha Generic

A

Evolocumab

26
Q

Evolocumab Dose

A

120 mcg q 2 weeks

420 mcg monthly

27
Q

Evolocumab Side Effects

A 
GI side effects
↑ LFT
Injection site reaction
Myalgia
Influenza
28
Q

Evolocumab Monitoring

A

LDL-C within 4-8 weeks of starting or changing dose

Hypersensitivity

29
Q

Lovaza Generic

A

Omega-3-acid ethyl esters

30
Q

Omega-3-acid ethyl esters Dose

A

4 g daily

2 g BID

31
Q

Omega-3-acid ethyl esters Side Effects

A 
GI – diarrhea
Dysgeusia
Dyspepsia
Eructation
Nausea
32
Q

Omega-3-acid ethyl esters Monitoring

A

TG and LDL at baseline and periodically
ALT periodically
GI disturbances, skin changes, bleeding

33
Q

WelChol Generic

A

Colesevelam

34
Q

Colesevelam Dose

A
  1. 75 g once daily

1. 875 g BID

35
Q

Colesevelam Side Effects

A 
↑ TG
Constipation
Bloating
Nausea
Flatulence
↓ absorption of fat-soluble vitamins
Hypernatremia
Hyperchloremia
GI Obstruction
36
Q

Colesevelam Monitoring

A

FLP: Baseline, 3 months after, q 6—12 months after

Should not use if TG>300 mg/dL

37
Q

Questran/Prevalite Generic

A

Cholestyramine

38
Q

Cholestyramine Dose

A

4g (1 packet or scoop) once or 2 times daily

Max: 24 g/day

39
Q

Cholestyramine Side Effects

A 
↑ TG
Constipation
Bloating
Nausea
Flatulence
↓ absorption of fat-soluble vitamins
Hypernatremia
Hyperchloremia
GI Obstruction
40
Q

Cholestyramine Monitoring

A

FLP: Baseline, 3 months after, q 6—12 months after

Should not use if TG>300 mg/dL

41
Q

Colestid Generic

A

Colestipol

42
Q

Colestipol Dose

A

Start: 5g once or twice a day
Increase by 5g at 1-2 month intervals
Go up to 30g/day or in divided doses

43
Q

Colestipol Side Effects

A 
↑ TG
Constipation
Bloating
Nausea
Flatulence
↓ absorption of fat-soluble vitamins
Hypernatremia
Hyperchloremia
GI Obstruction
44
Q

Colestipol Monitoring

A

FLP: Baseline, 3 months after, q 6—12 months after

Should not use if TG>300 mg/dL

45
Q

Niacor/Niaspan/Slo-Niacin Generic

A

Niacin

46
Q

Niacin Dose

A

Start: 500 mg at bedtime for 4 weeks
Go to 1 g at bedtime for 4 weeks
Max: 2g/day
Usual: 1-2 g/day at bedtime

47
Q

Niacin Side Effects

A

Prostaglandin mediated flushing and itching
Skin rash
Upset stomach
Low blood pressure when standing

48
Q

Niacin Monitoring

A

LFT baseline
FBH or A1C
Uric acid
Monitor during titration and every 6 months after

49
Q

Lopid Generic

A

Gemfibrozil

50
Q

Gemfibrozil Dose

A

600 mg BID 30 mins AC
Adjust following lipid determinations at 4-8 week intervals
Consider reducing if lipids significantly lower than target

51
Q

Gemfibrozil Side Effects

A 
GI disturbances
Rash
Myalgia
Dizziness
Anemia, leukopenia, thrombocytopenia
Renal insufficiency
52
Q

Gemfibrozil Monitoring

A

Serum cholesterol
LFTs
CBC – first year

53
Q

Tricor Generic

A

Fenofibrate

54
Q

Fenofibrate Dose

A

48-145 mg/day
Max: 145 mg/day
Adjust following lipid determinations at 4-8 week intervals
Consider reducing if lipids significantly lower than target

55
Q

Fenofibrate Side Effects

A 
GI disturbances
Rash
Myalgia
Dizziness
Anemia, leukopenia, thrombocytopenia
Renal insufficiency
56
Q

Fenofibrate Monitoring

A

Periodic blood cell count: first year
FLP every 6-8 weeks until goal then every 4-6 months
LFTs
Renal function: Baseline, 3 months after, every 6 months

57
Q

Trilipix/Fibricor Generic

A

Fenofibric Acid

58
Q

Fenofibric Acid Dose

A

Trilipix: 45-135mg/day
Max: 135mg/day
Fibricor: 35-105 mg/day
Max: 105 mg/day
Adjust following lipid determinations at 4-8 week intervals
Consider reducing if lipids significantly lower than target

59
Q

Fenofibric Acid Side Effects

A 
GI disturbances
Rash
Myalgia
Dizziness
Anemia, leukopenia, thrombocytopenia
Renal insufficiency
60
Q

Fenofibric Acid Monitoring

A

Periodic blood cell count: first year
FLP every 6-8 weeks until goal then every 4-6 months
LFTs
Renal function: Baseline, 3 months after, every 6 months

61
Q

Vytorin Generic

A

Simvastatin and Ezetimibe

62
Q

Juvisync Generic

A

Simvastatin with Sitagliptin

Therapeutics (7 decks)

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