Hyperlipidemia

Question 1

What are the risk factors for SAMS? Name 3

statin- associated muscle symptoms

Answer 1

1. Age >75yr
2. female
3. Low BMI
4. Asian descent
5. CYP mutations
6. high level of physical activity
7. severe CKD
8. dietary effects (excessive grapefruit ⇒ induce CYP), excess alcohol, drug abuse
9. acute infection
10. hypothyroidism
11. surgery w/ high metabolic demands –> consider w/holding statins beffore major surgery

Question 2

What findings are indicative of rhabdo?

Answer 2

Creatine Kinase > 40x ULN,
renal impairment,
± myoglobinuria

kidney damage due to leakage of myoglobin & other metabolites