Hyperlipidaemia Flashcards
1
Q
What is it?
A
Abnormally high levels of lipoproteins in plasma
2
Q
What are the causes?
A
Primary
- due to genetic disposition to abnormal lipid metabolism
- e.g. familial hypercholesteraemia
Secondary
- due to systemic metabolic disturbances
- obesity
- excessive alcohol
- diabetes
- drugs e.g. thiazides, non selective beta blockers
3
Q
What is the management?
A
Conservative
- weight loss
- increased exercise
- low fat diet
- high fibre
If QRISK2 >10% (Primary prevention)/ T1DM/ eGFR <60ml/min
-atorvastatin 20mg od
Secondary prevention (IHD/CVD/PAD) -atorvastatin 80mg od
4
Q
When is a statin given in T1DM?
A
In patients with diabetes who are
- > 40
- Diabetes >10yrs
- established nephropathy
- other CVD risk factors
5
Q
When should follow up be completed?
A
Repeat bloods in 3 months
- should see at least 40% drop in non HDL levels
- if not check diet and concordance and consider increasing dose
Should also monitor LFTs
6
Q
When is familial hypercholsteraemia diagnosed?
A
When Lipids >7.5mmol/L or 6.7 (children)
PLUS
For definite diagnosis
-DNA evidence/ tendon xanthoma in pt or in first or second degree relative
For probably diangosis
- MI <50 in second degree relative
- MI <60 in first degree relative
- FH of high cholesterol
7
Q
What is the management of familial?
A
High dose statins
Screening in children by age 10 if one parent with condition or by age 5 if both parents have condition
