Hyperlipidaemia (1)

Question 1

What are Lipoproteins?
→ What are its 4 types?

How is it classified?

What are the investigations to do?

When should familial hypercholesterolaemia be considered?

Answer 1

➊ Lipids packaged with proteins, allowing it to be transported around the body
→ • Chylomicrons and VLDL - mainly TGs
• LDL - mainly cholesterol
• HDL - Mainly phospholipids

➋ • Inherited - Familial Hypercholesterolaemia
• Secondary - DM, Hypothyroidism, Nephrotic syndrome, Drugs

➌ • Total cholesterol, LDL, HDL, and TGs
• Exclude secondary causes - HbA1c, TFT, U&E, LFT

➍ Total cholesterol > 7.5 mmol/L

Question 2

What score should be calculated in these pts?
→ How are pts managed depending on this?

What’s the 1st line option?
→ What’s its main SE?

Answer 2

➊ QRISK - 10 yr risk of CVE
→ • < 10% - Lifestyle changes
• > 10% - Give Statins

➋ Atorvastatin
→ Muscle aches