Hyperhidrosis Flashcards
innervation of eccrine gland, fluid secretion; MOA of AlCl, Bot tox; Tox of AlCl, Bot tox; use of 4* amine antimusc over 3*amines; modify sweat secretion exent
What is the molecule for post gang sympa innervation of eccrine glands?
Ach
molecule for post gang sympa for apocrine glands?
catecholamines
How does hypothalamic center regulate body temp?
bloodflow to skin and eccrine sweat output
What controls sweat during emotional and physical activity
limbic system
What are the 4 keys to the MOA for botulinum toxin?
Binding; internalizing (endocytosis); blocking; sprouting
What is the binding portion of the MOA for bot tox
heavy chain portion binds to cell membrane via high affinity acceptor molecule
blocking part of MOA for bot tox?
light chain cleaves protein (SNAP25) that enables fusion of Ach vesicles w/ membrane
By cleaving SNAP25 and fusion of Ach vesicles, what else is blocked via the MOA of bot tox
blocks release of pain neuropeptides (substance P, glutamate, CGRP)
Define sprouting in the MOA of bot tox
new nerve ending sprout and reconnect the muscle that renews neuromuscular coupling
How can bot tox cause muscular paralysis
block both muscarinic and nicotinic receptors
What are the effects of the rare systemic botulism
respiratory arrest/death; typical anticholinergic effects (dry mouth, pain at injection, double vision)
Why are allergies associated with bot tox?
it contains albumin
How does diltiazem help in hyperhidrosis?
blocks Ca channels in the secretion process
Eccrine sweat glands and vascular smooth muscle in skeletal muscle what type of fibers
sympa cholinergic dilator fibers
How does glycopyrrolate work?
systemic antimuscarinic agent in off label usage; quaternary ammonium compound do not have this problem
