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YR 5 pathology > hypergammaglobulinemia > Flashcards

hypergammaglobulinemia Flashcards

1
Q

what is hypergammaglobulinemia

A

increased production of antibodies in response to infection/malignancy

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2
Q

types of hypergammaglobulinemia

A

monoclonal
polyclonal

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3
Q

difference between monoclonal/polyclonal hypergammaglobulinemia

A

monoclonal- increased antibody production from one cell type

polyclonal- increased antibody production from different cell types

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4
Q

causes of hypergammaglobulinemia

A

infection - malaria
multiple myeloma
rheumatoid arthritis
liver disease
genetic

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5
Q

symptoms/signs of hypergammaglobulinemia

A

fever
fatigue
swollen lymph nodes

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6
Q

investigations for hypergammaglobulinemia

A

FBC (raised WCC)
high gamma globulins
some antibodies deficient

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7
Q

management for hypergammaglobulinemia

A

treat cause
immunoglobulin replacement of deficient ones? (uncommon)

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8
Q

treatment for malaria

A

antimalarial drugs

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9
Q

treatment for rheumatoid arthritis

A

DMARDs (methotrexate/ hydroxychloroquine)
+ short term steroids (prednisolone)/ NSAIDs (ibuprofen)

  1. biologics (adalimumab)
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YR 5 pathology (9 decks)

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