Hyperemesis gravidarum Flashcards
What is the first line anti-emetic treatment for hyperemesis gravidarum after conservative measures?
Cyclizine or promethazine (H1 receptor antagonists)
What vitamin is thiamine?
vitamin B1
When can you make a diagnosis of HG?
first trimester
When should other causes be considered?
if after 10+6 weeks
When does NVP typically resolve?
90% by 20 weeks
How do you diagnose HG?
severe nausea, weight loss >5% and electrolyte disturbances/dehydration
What do you use to classify severity?
PUQE - pregnancy-unique quantification of emesis
Metoclopramide - Mechanism of action
dopamine D2 receptor antagonist
Adverse effect of ondansetron
Prolongation of QT
Ondansetron - mechanism of action
serotonin selective 5HT3 antagonist
What is pyroxidine?
Vitamin B6 - not recommended
What is vitamin B12
cobalamin
When should corticosteroids be used for HG?
When all other treatments have failed
Which receptors does diazepam bind to?
GABA type A
prochlorperazine- mechanism of action
dopamine D2 receptor antagonist
promethazine - mechanism of action
H1 receptor antagonist
cyclizine - mechanism of action
H1 receptor antagonist
chlorpromazine - mechanism of action
dopamine D2 receptor antagonist
antiemetic dopamine d2 receptor antagonists
prochlorperazine
chlorpromazine
metoclopramide
domperidone
antiemetic H1 receptor antagonists
cyclizine
promethazine
antiemetic- serotonin selective 5HT3 receptor antagonist
ondansetron
domperidone - mechanism of action
d2 d3 dopmine receptor blocker
first line antiemetics
cyclizine
prochlorperazine
chlorpromazine
promethazine
second line antiemetics
domperidone (prokinetic)
ondansetron
metoclopramide (prokinetic)
Third line antiemetics
corticosteroids
PUQE 3-12
home management
PUQE 13 + no complications
ambulatory care until no ketonuria
Any PUQE with complications
admit IV hydration and antiemetics
