Hyperaldosetonism

Question 1

What is the human name of hyperaldosteronism

Answer 1

Conn’s syndrome

Question 2

What is hyperaldosteronism

Answer 2

Hyperplasia or neoplasia of the adrenal glands that will cause the overproduction of Aldoseterone

Question 3

What is aldosterone production stimulated by

Answer 3

Angiotensin 2 and increased potassium

Question 4

Where is aldosterone released from and what does it effect

Answer 4

Released by Zona Glomerulosa
Effects mineralocorticoid receptors in the distal renal tubules stimulating sodium reabsorption and potassium and hydrogen excretion
It mediates Vasoconstriction (increase production of prostacyclin, up-regulates ET production, ACE, Ang II, and AT1 receptors) which will cause hypertension

Question 5

What are some clinical signs of hyperaldosteronism

Answer 5

Hypokalemic - inappetence, weakness, head down
Hypertension - retinal detachment, ocular haemoohage, kidney damage, cardiac hypertrophy

Question 6

How do you diagnose hyperaldosteronism

Answer 6

Will see high ALDO and low plasma renin activity
U/S or CT to identify tumors

Question 7

How do you treat hyperaldosteronism

Answer 7

MEDICAL MANAGEMENT FISRT then six
Stabilize hypertension and potassium loss with spirolactone, potassium supplementation, and amlodipine
Can do unilateral adrenalectomy or continue with medical management

Question 8

Which is better for prognosis in hyperaldosteronism cases, medical management or surgery

Answer 8

Either, both have same prognosis regardless if the neoplasia is a carcinoma or adenoma