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Endo II: Test 2 > Hyper/Hypothyroidism > Flashcards

Hyper/Hypothyroidism Flashcards

1
Q

sx of hyper thyroidism?

A 
heat intolerance
palpitations
tachycardia
irritable/nervousness
loose stools
tremor
moist warm skin
mm. wasting
hyperreflexia
neck enlargement
clubbing of fingers
pretibial myxedema
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2
Q

typical findings of Grave’s?

A

goiter, exopthalmos, pretibial myxedema

Labs: Decreased TSH
High free T4
High free T3

  • Thyroglobulin Abs
  • Thyroid peroxidase Abs
  • TSH receptor antibodies act on the follicular cell (GPCR)*, fibroblast in the eye and pretibial skin.

Thyroid scan: shows increased uptake

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3
Q

what type of hypersensitivity is Grave’s?

A

Type II ( IgG antibody dependent cytotoxicity – antibodies to cell surface receptors or other cell surface components)

  1. complement mediated lysis (MAC);
  2. antibody dependent cytotoxic attack (K cells);
  3. alter cell surface receptor function by function toward activation or blockade (
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4
Q

which HLA seen in Grave’s?

A

HLA-DRB1, DR8

** Its a MHC class II cell surface receptor - stimulates TH2 cell response and production of antibodies from B cells

CD4 T cells (TH2) also stimulate TSH receptor antibodies (TSIs) (also ANA, anti-thyroperioxidase antibodies, and anti-thyroglobulin antibodies) that act on follicular cells to stimulate thyroid growth and secretion. They also cross-react with antigens in fibroblasts, adipocytes, etc.

** see TH1 response in Grave’s as well w/ pretibial myxedema and Graves orbitopathy

CD4 T cells (TH1) secret cytokines that stimulate effector cells (macrophages, cytotoxic T cells, NK cells, etc) against TSH receptors and fibroblast to produce glycosaminoglycans (GAG, hyaluronic acid).

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5
Q

cause of “staring”, lid lag, and strabismus seen in Graves? pretibial myxedema?

A

Fibroblast proliferation with GAG deposits, and lymphocyte infiltration in the muscles around the eyes produce proptosis and diplopia.

Pretibial myxedema:
The same thing can happen in the skin when the TSH receptors are attacked.

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6
Q

heart problems assoc. w/ grave’s?

A

Thyrotoxic cardiomyopathy: tachycardia induced cardiomyopathy,
AF, high output failure, and pulmonary hypertension.

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7
Q

Why is calcium elevated in hyperTH?

A

Increased T3 leads to increased bone turnover.

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8
Q

Which hormone is imp. to differentiate exogenous hyperTH from Grave’s?

A

elevated thyroglobulin indicates the thyroid is actively making thyroid

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9
Q

Causes for hypercalcemia?

A

SPERM DIF

Sarcoid (or any granulomatous disease)
Primary Hyperparathyroidism, Paget’s
Endocrine disease (Pheo, Addisons, HyperT)
Renal disease (diuretic phase of ARF, dialysis)
Malignancies (hypokalemic alkalosis), Milk Alkali
Drugs (Vit D, Vit A, lithium, thiazides)
Immobilization, Immune deficiency syndrome, inflammatory disorders
Familial hypocalcuric hypercalcemia

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10
Q

Treatment of Grave’s hyperTH?

A

1a. Antithyroid (thiourea) drugs:
- Block oxidation (TPO inhibition of I- to Io) , organification (iodination) and coupling– usually used up to four days before RAI to avoid RAI induced storm.
1. PTU* – OK in Pregnancy (1st trimester only). Blocks T4–>T3.
2. methimazole – less hepatic necrosis and drug of first choice.
Side effects of both: Agranulocytosis, Hepatitis,

1b. Iodine – (Iopanoic acid or Ipodate sodium) which block T4–>T3
(give after starting thiourea drugs) - works via peripheral inhibition of 5’ monodeiodination of T4. Wolff-Chaikoff effect – stops synthesis and release.

  1. RAI unless pregnant - may start with propranolol and anti-thyroid drugs (PTU qid or methimazole daily).
  2. Surgery
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11
Q

factors that can simulate primary hyperTH via creating low TSH?

A

Drugs: steroids, CCBs, dopamine, NSAIDS, opiates

elderly euthyroid

pregnancy/hCG secretion: hCG looks like T3/4, thus TSH is sometimes turned off during pregnancy

severe non-thyroidal illness = euthyroid sick syndrome

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12
Q

which drug can give you hyper/hypothyroidism/thyroiditis?

A

amiodarone : can activate autonomous thyroid nodules to become MNG

Type I amiodarone induced thyrotoxicosis – can be a Jod Basedow type with TMNG and no thyroid antibodies or an actual Graves type with antibodies.

Type II Amiodarone induced thyrotoxocosis - Thyroiditis

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13
Q

apathetic hyperthyroidism

A

apathy, w/l, angina, AF, CHF and less adrenergic symptoms

  • found in functioning thyroid nodules or toxic multinodular goiters
  • NOT an AI disease, thus won’t see an Abs developed - rather related to somatic mutations of the TSH receptor and cAMP cascade of inositol phosphate pathway
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14
Q

scan of TMNG?

A

decreased uptake of iodine

“Jod-Basedown phenomenon” - can be caused by amiodarone

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15
Q

causes of high RAIU other than Graves?

A

GAIT2

Graves
Adenoma (Plummers)
Inappropriate secretion of TSH (pituitary adenoma) -rare
Toxic Multinodular Goiter
Trophoblastic* (Embryonal carcinoma and Hydatiform mole - hCG – looks like TSH to the thyroid),

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16
Q

tx for AFTN/TMNG?

A

AFTN – RAI (Na 131I) or surgery (under age 40) or ATDs (usually given to avoid storm)

TMNG - RAI or Surgery or ATDs
For RAI treatment with low uptake – prime with PTU or recombinant TSH

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17
Q

subclinical hyperthyroidism

A

(usually d/t AFNs or MNGs)

see normal amount of T4, with very depressed TSH

Risks:

  • AF/diastolic dysfunction
  • osteoporosis
  • dementia

tx:
- RAI or small dose ATD

18
Q

what levels of TSH should just be tx w/ observation and beta blocker?

A

TSH Between 0.1- 0.3 mIU/L treat with observation and consider a beta blocker (blocks T4 –> T3), etc.

19
Q

Thyrotoxic Crisis or Storm

A

caused by an acute illness, thyroid
surgery or RAI therapy in an inadequately treated thyrotoxicosis
patient.

Manifested by fever (>102F), tachycardia, tachypnea,
hypotension, vomiting, diarrhea, irritability, delirium, coma
and death. May have anemia, increased BUN, Ca, SGPT, and glucose.

Treatment: Thiourea ( methamizole 30 mg every 6 hours or
PTU 200 mg every 6 hours) with iodides (Ipodate or SSKI) started
1 hour after the thiourea. Also start metoprolol and hydrocortisone.

20
Q

Thyrotoxic Periodic Paralysis

A

a condition featuring attacks of muscle weakness in the presence of hyperthyroidism Hypokalemia is usually present during attacks –> risk of arrhythmias

hx: oriental male, mm. pain/weakness, recurrent episodes, increased appetite, increased BP, increased HR, decreased reflexes, low potassium

cause:
- a channelopathy with muscle weakness (K+ being transferred into muscle cells from increased Na/K–ATPase activity with resultant hypopolarization and serum hypokalemia)
- occurring with a heavy meal* or post exercise in Asian men
- Thyroid hormone increases the ATPase activity as does catecholamines, insulin and testosterone, etc.
(often have underlying Grave’s) resulting in increased K+ in
- channelopathy involves L-Ca2+ channel along with K voltage gated channel

21
Q

postpartum thyroiditis

A

sx:
- post-partum female
- shakiness, palpitations, heat intolerance
- non-tender thyroid
- fine tremor in hands
- wide pulse pressure

Labs:
- see elevated T4, low TSH
- TPO antibodies present
see DR3, DR5

precursor to hashimotos

RAI scan shows: very little uptake

22
Q

causes of hyperTH assoc. w/ decreased RAIU?

A
  1. Drugs: Thyroxine (low serum TG level)
  2. Iodine: amiodarone type I
  3. Ectopic production
  4. Painful Thyroiditis:
    - Subacute Granulomatous (deQuervain’s): HLA B-35, viral , high ESR
    - suppurative (staph infection)
    - amiodarone type II
    - radiation / trauma
  5. painless (silent) thyroiditis:
    - Postpartum – DR3, DR5 (precursor to Hashimotos).
    - Subacute or chronic autoimmune (lymphocytic) – diabetes, vitiligo, Downs or Turners syndrome.
    - Riedel’s fibrosis (Normal or low uptake and function).

Note: Most cases of thyroiditis produce only a transient hyperthyroidism over a few months
transforming to hypothyroidism and then normal function or permanent hypothyroidism

23
Q

subacute granulomatous thyroiditis

A
  • painful thyroiditis

- (deQuervain’s): HLA B-35, viral , high ESR

24
Q

myxedema/ hypothyroidism sx?

A
  • dry brittle hair
  • edema of face/eyelids
  • coldness
  • diminished perspiration
  • slow pulse
  • ascites
  • mm. weakness
  • slow reflexes
  • deep voice
  • enlarged heart
  • numbness in hands/fingers
    • Tinel’s sign
  • jaundice
  • diastolic HTN
  • lethargy, memory impairement
  • doughy skin = lymphedema w/ accumulation of GAGs in skin
  • loss of lateral 1/3 of eyebrows (queen Anne’s sign)
25
Q

ten Hypos of HypoTH

A

Hyporeflexia
Hypomentia
Hypothermia
Hypoventilation
Hypotension or diastolic HTN
Hypohemoglobinemia
Hypoglycemia
Hyponatremia (decreased renal Na/K ATPase)
Hypometabolism of drugs and lipids (hyperlipidemia)
Hypocorticolism (pituitary insufficiency)
Hypoadrenalism(Addison’s disease)

26
Q

Hashimoto’s disease

A

Chronic Lymphocytic Thyroiditis with HLA-DR5.

Antibodies to TPO
and thyroglobulin.

The thyroid is usually enlarged and boggy. Spotty uptake with low, high or normal RAI.

27
Q

subclinical hypothyroidism

A

– Normal T4 but high TSH, see TPO Abs

Risks:

  • Elevated lipids.
  • CHF and ASHD (especially if TSH > 10mIU/L).
  • Early dementia, neuropsychiatric symptoms, and depression.
  • Poor iron absorption (anemia).

Tx: ** know this**

  • Treat for TSH is >5 mIU/L if anti TPO antibodies are present.
  • If no Abs, treat TSH>10
  • treat pregnant pts w/ TPO antibodies and TSH >2.5
28
Q

when to tx hypothyroidism?

A

Tx: ** know this**

  • Treat for TSH is >5 mIU/L if anti TPO antibodies are present.
  • If no Abs, treat TSH>10
  • treat pregnant pts w/ TPO antibodies and TSH >2.5
29
Q

causes of hypoTH?

A
  1. Chronic lymphocytic thyroiditis (Hashimotos)
  2. RAI* induced hypothyroidism after treatment of Graves
  3. Subacute lymphocytic thyroiditis
  4. Drugs - iodine, PTU, lithium, interferon, amiodarone
  5. Irradiation and thyroidectomy
  6. Infiltrative diseases
  7. Hepatitis C - increased propensity to antithyroid antibodies
  8. Central hypothyroidism
  9. Congenital defects
  10. Iodine deficient goiter.
30
Q

what other AI diseases occur w/ Hashimotos?

A

Addisons, hypoparaT, DM, PA, Sjogren’s, vitiligo, PBC, IBD, etc.

31
Q

Wolff-Chaikoff effect?

A

= a reduction in thyroid hormone levels caused by ingestion of a large amount of iodine
- Patients with Graves’ disease are more sensitive than euthyroid patients, and iodine has been used to manage Graves’ disease.
- Iodine administration blocks the organification and hormone release
- usually occurs in patients with underlying autoimmune
thyroiditis.

32
Q

causes of + Tinel’s sign?

A

“medium trap”

Myxedema (HypoTH)
Edema
Diabetes
Infiltration (sarcoid, leukemia, fibrosis)
Amyloid
Neoplasms

Trauma
RA
Acromegaly
Pregnancy

33
Q

Gallavardin phenomenon

A

aortic murmur (d/t aortic insufficiency/hypthyroidism) - referred to apex, making you think you have mitral murmur along with aortic

see elevated diastolic BP

34
Q

what heart and electrolyte disturbances seen with hypoTH?

A
  • aortic murmur
  • diastolic HTN
  • elevated CPK (but normal tropinin)
  • elevated cholesterol
  • lowered Na+ (see hyponatremia, euvolemia - b/c decreased CO and increased ADH secretion)
  • decreased iron, with increased TIBC
35
Q

tx of hypothyroidism?

A

Start with L-thyroxine 25-75 mcg/day, unless pregnant (start with 100-150 mcg) or Hx of CAD (start at 25 mcg)

Keep TSH between 0.5 mU/L – 2.0 mU/L

For those still feeling tired at TSH < 2mU/mL, check for anemia, B12 deficiency, and sleep apnea. May consider low dose T3

36
Q

myxedema crisis

A

Precipitated by medicine non-compliance, surgery, stress, infections, etc.

10 hypos: hypothermia, hypoventilation, hyporeflexia,
hypoglycemia, hyponatremia, hypoxemia, etc

20-50% mortality

Lethargy and stupor to “myxedema coma”

Treatment:
Hydrocortisone 100 mg IV followed by 300 mcg levothyroxine(LT4) IV, over 5 minutes, followed by LT3 20-50 mcg IV over 5 minutes

*** must give cortisone first

37
Q

causes of low TSH

A
  • AFTNs (autonomously functioning thyroid
    nodules) or MNG.
  • Drugs: acute steroid administration,
    amphetamines, calcium channel blockers, dopamine, NSAIDS, opiates.
  • Elderly euthyroid.
    -Pregnancy or hCG secretion.
  • Severe non-thyroidal illness (interleukins, TNF –
    Euthyroid sick syndrome).
38
Q

dopamine does what to TSH?

A

suppresses TSH

39
Q

Euthyroid sick syndrome

A

Causes: illness or major surgery

  1. “Sick enzymes” and serum inhibitors with low total T3, low free T3, low total T4, and high reverse T3

due to:
a. Decreased 5’deiodinase (esp liver) = Low T3 and high rT3 (surgery)

b. Increased interleukin = displaced binding of T4 (major illness) = decreased total T4 and increased T3 uptake
2. Low TSH with severe euthyroid sick syndrome due to:
a. Drugs: acute steroid administration, amphetamines, calcium channel blockers, dopamine, NSAIDS, opiates
b. increased IL-1, IL-6 and TNF alpha (IL-s drop TSH)

40
Q

Prolactinomas and TRH?

A

thyrotrope hyperplasia and increased TRH –> stimulates prolactin production –> may produce an adenoma which is considered a prolactinoma or TSH secreting adenoma

(see high levels of TRH/TSH in hypothyroidism)

Endo II: Test 2 (10 decks)

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