Hydrocortisone Sodium Succinate (Solu-Cortef)

Question 1

Classification

Answer 1

Corticosteroid, anti-inflammatory

Question 2

Mechanism of Action

Answer 2

• Replaces the naturally occuring hormone, cortisol, produced in adrenal cortex
• Minimizes allergic response by inhibiting histamine formation, storage, and release from mast cells

Question 3

Indications

Answer 3

• Allergic reactions
• Severe anaphylaxis
• Asthma
• COPD

Question 4

Contraindications

Answer 4

• Hypersensitivity

Question 5

Adverse Effects

Answer 5

• Fluid retention, CHF, HTN, tachycardia
• Vertigo, headache
• Abdominal distention, nausea, vomiting, hiccups
• Malaise, petechiae

Question 6

Administration

Answer 6

• Adult: 40-250 mg SIVP at 25 mg/min; or deep IM
• Peds: 4-8 mg/kg/day SIVP; or deep IM

Question 7

Special Considerations

Answer 7

• When indicated there are few precautions for acute prehospital emergency care
• Not a first line drug. Considered an adjunct.
• IV route preferred in emergency care
• Supplied in vials. Powder must be reconstituted in a diluent. Do not shake vial.
• Caution with CHF, HTN, diabetes, or kidney disease