Huntington's

Question 1

Huntington’s essentially leads to?

Answer 1

Decreased output from STN (hyperkinetic)

Question 2

Huntington dz tx is symptomatc. What drugs do you use to treat the depression?

Answer 2

1. Fluoxetine (SSRI)

2. Carbamazepine (Na channel blocker)

Question 3

What drugs do you use to treat the chorea?

Answer 3

1. Reserpine & Tetrabenazine –> cause depletion of dopamine

2. Chlorpromazine & Haloperidol –> D2 antagonists –> increase indirect pathway –> decrease movement