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A AG ext. > Huntington disease > Flashcards

Huntington disease Flashcards

1
Q

HD - effects of blocking dopamine receptors

A

Improvement of motor function.

Relieve psychosis.

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2
Q

Only drug that may treat chorea in HD

A

Tetrabenazine

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3
Q

Drugs for HD - 3 drugs

A

Tetrabenazine
Diazepam, benzos
Haloperidol, other antipsychotics.

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4
Q

Tetrabenazine - MOA

A

Reversible inhibition of the human vesicular monoamine transporter type 2 (VMAT2), resulting in decreased uptake of monamines into synaptic vesicles and depletion of monoamine stores (dopamine, serotonin, norepinephrine).

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5
Q

Diazepam and benzos- when is it most effective in treatment of HD?

A

When there are GABA neurons still alive.

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6
Q

Diazepam - adverse effects

A 
Arrhythmias
CNS depression
Drug dependence
Hypotension
Mild respiratory depression
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7
Q

Diazepam - interactions

A

Alcohol and other CNS depressant potentiate effects.

Cimetidine increases and rifampin decreases serum levels.

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8
Q

Haloperidol - adverse effects

A

Extrapyramidal side effects and increased prolactin levels.

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9
Q

Haloperidol - interactions

A

Barbiturates and carbamazepine decrease and quinidine increases serum levels

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A AG ext. (12 decks)

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