Human Physiology Flashcards

1
Q

cell/plasma membrane

A

separates intracellular contents from extracellular environment

  • guards internal structure and keeps products inside cell
  • allows for transport in & out
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2
Q

protoplasm

A

inner matrix that contains water, electrolytes, proteins, carbs (cytoplasm contains organelles)

  • water = majority of protoplasm
  • proteins = polar & hydrophilic
  • lipids = non-polar & hydrophobic
  • carbs = rapid source of energy
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3
Q

nucleus

A

control center; contains most of the hereditary material

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4
Q

proteins

A

polar & hydrophilic, makes up 10-20% of protoplasm composition

  • enzymes
  • structural proteins
  • ion channels
  • receptors
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5
Q

lipid bilayer

A

basic fluid structure of membranes that serves as semipermeable barrier
* maintains fluid balance
comprised of:
> phospholipids (amphipathic) -hydrophilic head and hydrophobic tail
> cholesterol (hydrophobic)

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6
Q

integral proteins

A

require something to open membrane

-allows substance to change shape and enter

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7
Q

glycocalyx

A

participates in cell to cell recognition and adhesion

  • fuzzy membrane (sugar coat)
  • way for cells to identify others
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8
Q

functions of cell membrane

A
  • physical isolation -> barrier
  • regulates exchange w/ environment - maintains homeostasis
    ex) prevents hyperkalemia and arrhythmia
  • monitor environment through extracellular fluid composition and chemical signals
  • structural support- anchors cells/tissues
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9
Q

anchoring protein

A

integral/transmembrane protein that is a stabilizer

  • attaches to inside or outside of structures
    ex) skin intact and does not slough off normally
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10
Q

recognition proteins

A

integral/transmembrane protein that is an identifier

-labels cells as normal or abnormal

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11
Q

enzymes

A

integral/transmembrane protein that catalyzes rxns

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12
Q

receptor proteins

A

integral/transmembrane protein that bind & respond to ligands (lock & key)
ex) ions, hormones

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13
Q

carrier proteins

A

integral/transmembrane protein that transport specific solutes through membrane

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14
Q

channels

A

integral/transmembrane protein that regulate water flow & solutes through membrane
ex) facilitated diffusion in aqua porins

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15
Q

peripheral proteins

A

bound to inner or outer membrane

  • integral protein
  • allows substance to change shape & enter cell
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16
Q

cell junctions

A

form bonds w/ other cells/extracellular material
-attaching cells/communication between cells
» tight
» gap
» desmosomes

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17
Q

tight/occluding junctions

A

fused together between 2 cell membranes = impenetrable barrier

  • prevents passage of water & solutes
  • found only in epithelial tissue
    ex) skin, GI tract

*burn pts experience fluid loss (not infection) which can lead to death
&raquo_space; must monitor IV fluids

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18
Q

selective absorption of digestive tract

A

prevents bacteria from entering GI tract

ex) dissentaria & cholera -> disruption of barrier

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19
Q

gap junctions

A

strong adhesions between neighboring cells w/ cylindrical channels that permit ions and small molecules to pass between cells (ions, simple sugars)

  • allows for rapid communication
    ex) heart/intestines/smooth muscle require coordination of muscles to have same rate of contraction at the same time
20
Q

desmosomes

A

Anchoring junctions that hold together
adjacent cells by thick protein filaments;
extend through cell
Ex) Areas of mechanical stress; epidermis belosa

21
Q

Passive transport

A

no energy required

  • diffusion
  • filtration
22
Q

diffusion

A

type of passive transport

  1. Simple
  2. Facilitated/Carrier-mediated transport
  3. Osmosis (aquaporins) - movement of water
23
Q

active transport

A

requires energy
types include:
>primary- requires ATP directly to go against concentration gradient
>secondary- uses energy for transport of 1 substance for cotransport of 2nd substance
>vesicular transport - exocytosis, endocytosis

24
Q

carrier mediated transport of big/lipid soluble ions & organic substrates

A

use energy (2/2 active transport) or via facilitated diffusion

25
specificity
characteristic of carrier mediated transport | -Carrier proteins combine specifically and reversibly
26
saturation limit
characteristic of carrier mediated transport in which rate depends on transport proteins, not substrate ex) insulin brings glucose into cell
27
diffusion
movement of charged or uncharged particles along a concentration gradient from an area of higher concentration to one of lower concentration -passive process -no energy requires
28
osmosis
``` diffusion of water across the cell membrane -regulated by concentration of non- diffusible particles on either side of semipermeable membrane -net movement of water across a concentration gradient (from low concentration to high concentration) ```
29
hypotonic IVF
NS is not concentrated since it is 1/2 Na- | -water flows into cell
30
hypertonic IVF
water will flow out of cells
31
normal saline (NS)
Na+ and Cl- = about the same concentration in body
32
aquaporins
``` water channels that allows water to move -Movement continues until concentration of substances is equally diluted or until opposed by osmotic pressure ```
33
ADH
antidiuretic hormone stored in posterior pituitary gland - secreted by hypothalamus - goes to kidney -> distal tubular duct - prompt aquaporins to open - absorption of water -> reabsorption
34
SIADH
syndrome of inappropriate ADH - too much of ADH -> drop in Na- * Sodium Is Always Down Here*
35
Na- K+ pump
pumps out Na+ (3) pumps K+ in (2) ! Maintains Na-K concentration across membrane membrane ! Maintains normal cell volume > electrogenic ( negative charge inside cell membrane) > responsible for transmission of nerve and muscle signals along cell membrane -reestablishes proper concentration of electrolytes
36
Endocytosis
``` Vesicular/Bulk Transport that requires ATP >cells surround and take in material ! Receptor-mediated - pinocytosis - phagocytosis ```
37
exocytosis
Vesicular/Bulk Transport that requires ATP | -Granules or droplets are released from the cell
38
pinocytosis
type of endocytosis involved in nutrient absorption ! Endosomes “drink” extracellular fluid (Cell drinking) ! In-folding cell membrane surrounds droplet of ECF with dissolved molecules ! Important in nutrient absorption (cells in intestine)
39
phagocytosis
``` type of endocytosis -Engulf large or solid objects in phagosomes (Cell eating) -Fuses with lysosome and contents digested Ex: macrophages, some WBC’s ```
40
exocytosis
``` Moves substances from interior of cell into extracellular space ! Substance to be released is enclosed in a vesicle ! Vesicle fuses to membrane and ruptures, spilling contents out of cell ex) Hormone secretion, NT release, mucus of secretion, ejection of wastes ```
41
filtration
``` Process by which fluid is forced through membrane from area of higher hydrostatic pressure to area of lower hydrostatic pressure -does not require energy ex) Filtration of plasma across renal - dependent on BP ```
42
intracellular compartment (ICF)
-Consists of fluid contained within all of the trillions of cells in the body -Larger of the two compartments ! approximately two-thirds of the body water in healthy adults ! High concentration of K+ 40% of body weight
43
extracellular compartment (ECF)
remaining 1/3 of body of water -fluids outside the cells, including that in the interstitial (¾) or tissue spaces and blood vessels (¼) -high concentration of Na-
44
transcellular fluids
1% or less of the fluid in body ex) CSF in brain - vitreous humor in eye - synovial fluid lubricates joints - pericardial fluid in heart - pleural fluid in lungs
45
composition of ECF
- large amounts of Na- and Cl- - moderate amounts of bicarbonate ex) pH in body - ABG - small quntities of K+, Mg, Ca+, Phos
46
composition of ICF
-Almost no calcium -Small amounts of sodium, chloride, bicarbonate, and phosphorus - Moderate amounts of magnesium -Large amounts of potassium
47
voltage gated channels
``` -Respond to changes in membrane potential -Have activation gates (opens) and inactivation gates (closes) -Characteristic of excitable membrane -Found in neural axons, skeletal muscle sarcolemma, cardiac muscle ```