Human Pathology Cell Adaptation ( Pass) Flashcards
Atrophy
Shrinkage in the size of the cell by the loss of cell substance is known as atrophy
hormonal hyperplasia,
the proliferation of the glandular epithelium of the female breast at puberty and during pregnancy,
compensatory hyperplasia
in which residual tissue grows after removal or loss of part of an organ. For example, when part of a liver is resected, mitotic activity in the remaining cells begins as early as 12 hours later, eventually restoring the liver to its normal weight.
Physiologic adaptations
represent responses of cells to normal stimulation by hormones or endogenous chemical mediators (e.g., the hormone-induced enlargement of the breast and uterus during pregnancy).
Etiology
the origin of a disease, including the underlying causes and modifying factors.
Pathogenesis
the steps in the development of disease. It describes how etiologic factors trigger cellular and molecular changes that give rise to the specific functional and structural abnormalities that characterize the disease.
homeostasis
in which the intracellular milieu is kept within a fairly narrow range of physiologic parameters
The principal adaptive responses
hypertrophy, hyperplasia, atrophy, and metaplasia. If the adaptive capability is exceeded or if the external stress is inherently harmful, cell injury develops (
Reversible Injury
Cells return to a stable baseline
Irreversible Injury to Cells
Stress is constant and cell reaches a threshold of no return.
What are the causes of cell death?
It results from diverse causes: including ischemia (lack of blood flow),
infections,
toxins
immune reactions
Cell death also is a normal and essential process in embryogenesis,
the development of organs, and the maintenance of homeostasis.