Human Herpes Virus Beta Flashcards
1
Q
HHV Beta
A
Long reproductive cycle
Enlargement of infected cells
Slow cell-to-cell spread in culture
Multiple non-ganglionic latency sites
DNA virus
2 subtype: 6&7 (HHV-6B cause most disease)
2
Q
HHV-6 Pathogenesis
A
Inoculation of epithelial cells Primary viremia Salivary glands infected Latency -> may integrate into telomeres Reactivation -> Asymptomatic / Symptomatic (ImmCp)
3
Q
HHV-6 Tissue Tropism
A
Neural cells (astrocytes and glial cells) -> seizure during primary infection cephalitis in reactivation in ImmCp
4
Q
HHV-6 Clinical Manifestation
A
Fever, Fussiness, Diarrhea, Rash, Roseola Syndrome
Complication:
- Febrile seizure non-epileptic (10-20% caused by HHV-6)
- Reactivation in ImmCp
5
Q
HHV-6 Diagnosis
A
Clinical Diagnosis in healthy patient
PCR for ImmCp
6
Q
HHV-6 Treatment
A
Symptomatic tx in healthy
Antiviral agents in ImmCp
7
Q
HHV-6 Preventive
A
None
8
Q
HHV-7 Pathogenesis
A
Similiar to HHV-6, active and latent infection of CD4+T cells, persistent salivary infection
9
Q
HHV-7 Clinical Manifestation
A
Ubiquitous primary infection in childhood 50% serology at 2 years
No routine Dxg or Tx
