Human form and function 3 Flashcards
What do the adrenal cortex hormones mediate?
Long term stress responses
What is the adrenal cortex hormone function ?
participate in homeostatic regulation of metabolism.
What is the function of the glucocorticoids?
Glucocorticoids have a main effect on glucose metabolism and promote glucose synthesis from non-carbohydrate sources such as protein and fat so that more glucose is available in the blood circulation for cellular energy production.
These hormones can promote breakdown
of skeletal muscle proteins for synthesis of glucose when the body requires more glucose.
what is the main glucocorticoid?
cortisol
Main mineralocorticoid of adrenal cortex by adrenal gland
aldosterone
Adrenaline medulla hormones
The hormones produced in the adrenal medulla are adrenaline (epinephrine) and noradrenaline
(norepinephrine) which could mediate ‘short term stress responses
Upon extensive sympathetic nervous stimulation, What is the function of adrenal medulla hormones?
Secretes these hormones which can potentiate the “fight
or flight response” by increasing the heart rate and blood pressure, diverting blood to essential
organs (i.e heart, brain, skeletal muscles) and increasing metabolic rate.
The hormones secreted
by adrenal medulla are mainly involved in increasing the availability of chemical energy for
immediate use.
These hormones promote glucose release into the circulating blood by increasing
the rate of glycogen breakdown (in liver and skeletal muscles) and fatty acids release (from fat
cells) for energy production within the body cells.
What are the features of islets of Langerhans of the pancreas?
Pancreases can be considered an endocrine gland as well as an exocrine gland. It is located behind the stomach in the curve of the duodenum.
The endocrine part of the pancreas is the islets of
Langerhans which are clusters of cells scattered throughout the pancreas.
These pancreatic islets mainly secrete two hormones, glucagon and insulin which control the blood glucose level by opposing actions.
Alpha cells of the pancreatic islets secrete glucagon which mainly promote the blood glucose level increase.
Beta cells of the pancreatic islets secrete insulin which promotes
lowering of blood glucose level.
What are the main target sites of the pancreatic hormones?
Liver and skeletal muscles are the main target sites of these
hormones
What is the female gonad location?
pelvic cavity
Where do the paired male gonads lie in?
Paired male gonads (testes) lie in
the scrotum.
What are the functions of the ovaries and the testis?
In addition to the reproduction, ovaries and testes have endocrine functions.
What does the ovarian follicle and corpus luteum produce?
Ovarian follicle produces the hormone estrogen. Corpus luteum (the structure formed from
the ovarian follicle after ovulation) produces progesterone.
What are the functions of LH and FSH?
These female sex hormones along
with FSH and LH from the anterior pituitary regulate menstrual cycle, maintain pregnancy and
prepare mammary glands for lactation. They also help establish and maintain feminine sexual
characteristics. The ovaries also produce the hormone inhibin that inhibits secretion of FSH from
anterior pituitary.
What are the locations and the functions of the male sex hormones?
The main hormone produced and secreted by the testes (interstitial cells) is the male sex hormone,
testosterone. Testosterone regulates production of sperm and stimulates the development and
maintenance of masculine secondary sex characteristics. In addition, the testes (Sertoli cells)
produce inhibin that inhibits secretion of FSH.
Example for negative feedback mechanism of glucose metabolism?
In the absence of stimulation, the blood level of hormone will
decrease. Some hormone levels in the blood can be directly controlled by the blood levels of
the stimulus (e.g. insulin or glucagon by blood glucose levels). For example high blood glucose
levels stimulate the release of insulin hormone (from the pancreas) to the circulating blood which
acts on specifi c target tissues to lower the blood glucose level. When glucose level in the blood
reaches normal range, blood glucose level can in turn directly control the secretion of insulin
levels from the pancreas and prevent further lowering of the glucose level in the blood.
Example for negative feedback mechanism?
In the absence of stimulation, the blood level of hormone will
decrease. Some hormone levels in the blood can be directly controlled by the blood levels of the stimulus (e.g. insulin or glucagon by blood glucose levels).
For example high blood glucose levels stimulate the release of insulin hormone (from the pancreas) to the circulating blood which acts on specific target tissues to lower the blood glucose level.
When glucose level in the blood reaches normal range, blood glucose level can in turn directly control the secretion of insulin
levels from the pancreas and prevent further lowering of the glucose level in the blood.
Give an example for positive feedback mechanism
Positive feedback mechanisms involving oxytocin
hormone operate in childbirth and breast milk ejection
How do the positive feedback mechanisms occur? (1 way)
During labour, contractions of uterus are stimulated by oxytocin hormone released by the posterior pituitary. These contractions force the baby’s head into the uterine cervix stimulating its stretch receptors.
In response to stimulation
of stretch receptors, sensory neurons are stimulated again triggering more oxytocin release from
the posterior pituitary enhancing contractions of the uterus. This process repeats until the baby is
born. Afterwards oxytocin secretion stops as the stimulus
Name another way of positive feedback mechanism
During suckling, sensory neurons send the nerve impulses to the
posterior pituitary triggering release of oxytocin hormone to the circulating blood. Then oxytocin
acts on the mammary glands and induces contractions of smooth muscles in the mammary
glands to release milk. Milk release increases the sensory stimulus forming a positive feedback
that amplifi es the stimulus. In response to the positive feedback, more oxytocin is released
enhancing milk ejection
Name heat loss mechanisms
- dilation of blood vessels in the skin which causes fi lling of blood capillaries with warm
blood and radiating heat from the skin surface - increase sweat secretion from the sweat glands which promotes heat dissipation through
evaporative cooling
Name heat gain mechanims
constriction of blood vessels in the skin which divert the blood from the skin to deeper
tissues thereby reducing heat loss through the skin surface
- shivering: rapid repetitive contractions of skeletal muscles to generate heat
- contracting hair erector muscles to generate heat to some extent
- stimulating secretions of more thyroid hormones (e.g. thyroxin) and adrenalin into the
blood which increase the metabolic rate and cellular metabolism (especially oxidation of
fat in the liver) to produce more heat
When the blood glucose level rise up over the normal range?
High blood glucose levels exceeding the normal limits, stimulate the secretion of insulin hormone from beta cells of the islets of Langerhans into the circulating blood. Insulin acts on specific target tissues to promote lowering of the blood glucose level.
Insulin in the circulating blood stimulates transport of glucose into the body cells and use of glucose by body cells for ATP production
(glucose may be broken down into carbon dioxide and water), conversion of glucose to glycogen in liver and skeletal muscle cells for storage, and conversion of glucose to fatty acids and storage
of fat in adipose tissues.
When glucose level in the blood reaches normal range, blood glucose
level can in turn directly control the secretion of insulin levels from the pancreas through negative
feedback. This mechanism prevents further lowering of the glucose level in the blood beyond the
normal limits.
When the glucose levels are below the normal limits, what happens?
Low blood glucose levels below the normal limit, stimulate the secretion of glucagon from alpha cells of the islets of Langerhans into the circulating blood.
Glucagon acts on specific target tissues to promote increase of the blood glucose level.
Glucagon promotes the breakdown of glycogen in the liver and skeletal muscles and release of glucose into blood.
When glucose level in the blood reaches normal range, blood glucose level can in turn directly control the secretion of glucagon levels from the pancreas through negative feedback which prevents further increasing of the glucose level in the blood beyond the normal limits.
What happens when blood level increases beyond the normal limits?
Low blood glucose levels below the normal limit, stimulate the secretion of glucagon from alpha
cells of the islets of Langerhans into the circulating blood. Glucagon acts on specifi c target tissues
to promote increase of the blood glucose level. Glucagon promotes the breakdown of glycogen
in the liver and skeletal muscles and release of glucose into blood. When glucose level in the
blood reaches normal range, blood glucose level can in turn directly control the secretion of
glucagon levels from the pancreas through negative feedback which prevents further increasing
of the glucose level in the blood beyond the normal limits.
What are the ways by which the blood osmotic level is obtained?
controlling the amount of water and
controlling the amount of salt gained and lost by the body.
What are the ways by which the blood osmotic level is obtained?
controlling the amount of water and
controlling the amount of salt gained and lost by the body.
What happens when blood osmolarity is increased beyond the normal limits?
When blood osmolarity is increased beyond the physiological limits, it is sensed by the osmoreceptors in the hypothalamus which stimulates the posterior pituitary to release ADH to the blood circulation.
ADH acts on the kidney tubules and stimulates the reabsorption of water
through distal convoluted tubules of the nephrons and collecting ducts producing concentrated urine.
When blood osmolarity is decreased, ADH is not secreted, so water reabsorption through distal convoluted tubules of the nephrons and collecting ducts stop thereby producing diluted
urine.
In addition, low blood volume and low blood sodium ions stimulate the kidneys to produce angiotensin II which stimulates the adrenal cortex to secrete aldosterone hormone.
Aldosterone stimulates the reabsorption of sodium ions by the kidney tubules which is accompanied by the
water retention, thereby increasing blood volume and blood pressure. Hence, kidneys play a major
role in osmoregulation in the human body.
What is the role of liver in homeostasis?
Carbohydrate metabolism
Fat metabolism
Protein metabolism
Breakdown of erythrocytes and defense against microbial infections
Detoxification of drugs and toxicants:
Production of heat
Storage of nutrients
Inactivation of hormones
Secretion of bile
What are the ways of asexual reproduction?
Budding
Fragmentation and regeneration
Parthenogenesis
Explain what happens during budding
Budding is a form of asexual reproduction in which new individuals arise form outgrowths of the animal.
e.g. Hydra – A localized mass of mitotically dividing cells,
develops into a small Hydra, which can eventually detach from the parent.
What happens during fragmentation and regeneration?
This is a form of asexual reproduction which involves
breaking of the body or part of the body into several pieces, followed by the growth of a separate individual from each piece.
Each fragment develops into a complete animal by regrowth of lost body parts (regeneration). e.g. Certain annelid worms, numerous sponges,
cnidarians.
What takes place during parthenogenesis?
This is an unusual form of asexual reproduction in which an egg develops
into a complete individual without being fertilized. Among invertebrates, parthenogenesis
occurs in some animals such as bees, ants, aphids and wasps. The progeny can be haploid
or diploid. In honey bees – males (drones) are fertile haploid adults that develop through
parthenogenesis, whereas females including both sterile workers and the fertile queen, are
diploid adults that developed from fertilized eggs. Parthenogenesis has also been observed
very rarely among vertebrates (e.g. some lizards and fi sh).
Describe the nature of the female gamete during the sexual reproduction?
the egg,
is large and non-motile
Describe the nature of the male gamete during sexual reproduction?
the sperm, is generally much smaller and motile.
Describe about gamete formation during sexual reproduction
In animals, reproductive cells called gametes (sperms and eggs) are
the vehicles that transmit genes from one generation to the next. Each gamete is a haploid,
unicellular reproductive cell. Gametes in animals are formed by meiosis in special organs
called gonads.
What are bisexual organisms?
n a bisexual organism (Hermaphrodite),
one individual has both female and male reproductive structures and therefore is able
to produce both male and female gametes by the same individual. e.g. Earthworms
Explain about unisexual organisms
*In unisexual organisms (dioecious), one individual bears either male or female reproductive
structures.
*Therefore production of male or female gametes occurs in separate organisms.
e.g. Humans
What are the requirements for the external fertilization?
*occurs in aquatic environments.
*In species with external fertilization, the female releases eggs while the male releases sperm into the external environment and
fertilization occurs in the water.
A moist habitat is almost always required for external
fertilization both to prevent the gametes from drying out and to allow the sperm to swim toward the eggs. e.g. Many invertebrates, amphibians, most bony fish.
What are organisms that show internal fertilization?
insects, reptiles,
mammals.
Explain about the internal fertilization
Internal fertilization is an adaptation that enables sperm to reach an egg even when the environment is dry.
The male copulatory organ delivers sperm and the female
reproductive tract often has receptacles for storage and delivery of sperm to mature eggs.
Internal fertilization is typically associated with the production of fewer gametes than external fertilization but results in the survival of a higher fraction of zygotes.
Internal fertilization often provides greater protection to the embryos. Many animals show parental care.
Internally fertilized eggs of birds and other reptiles possess shells and
internal membranes that protect against water loss and physical damage. Some retain the
embryo for a portion of any development within the female reproductive tract.
What are the advantages of asexual reproduction?
Asexual reproduction allows rapid multiplication of individuals from single parents. Hence no time
or energy is needed to be spent in searching mates for the reproduction. In asexual reproduction,
there is no or very little genetic variation within a population as the produced off spring are
genetically identical to each other and to the single parent. Therefore, asexual reproduction would
be more advantageous in stable, favorable environments as it can propagate successful genotypes
specifi cally. However, any mutation in the parent cell, can cause harmful eff ects on the survival
ability of the off spring in changing environments. If there is a harmful mutation in the organisms,
environment changes could be deadly to all the individuals in the population.
Advantages of sexual reproduction
Unlike asexual reproduction, sexual reproduction results in the production of a unique off spring by
combining genetic materials from two parents. Meiotic recombination during sexual reproduction
helps produce varied genotypes. Unique gene combinations formed during sexual reproduction
would be advantageous as this can enhance reproductive success and survival of a species in
changing environments. Benefi cial gene combination arising through recombination may speed
up adaptation. During sexual reproduction, shuffl ing of genes might allow a population to clear
sets of harmful genes more readily which would enhance the survival of the species.
What are the functions of the reproductive organs of the reproductive system?
gonads (testes) which produce sperm
and reproductive hormones,
epididymis which store mature sperms, accessory glands that secrete
products required for sperm movement
ducts that transport the mature sperm and glandular
secretions
What are the external male reproductive organs?
The external reproductive organs of a male are the scrotum and penis.
Function of the sertoli cells?
These cells secrete the hormone inhibin and nourish and provide attachment
for cells that are in different stages of spermatogenesis
What is the function of the leydig cells?
secrete the hormone testosterone and other androgens after puberty which
promote spermatogenesis in the tubules
What is the function of the epididymis?
Matured sperms are stored within the epididymis
until ejaculation.
What does the urethra run through?
The urethra runs through the penis
and opens to the outside at the tip of the penis which contains erectile tissues derived from
modifi ed veins and capillaries.
What is the function of the ejaculatory duct?
The ejaculatory ducts open into the urethra which is the passageway for both urinary excretion and delivery of sperms in semen into the female reproductive tract
Explain the basic process of spermatogenesis?
formation of spermatocytes
from a spermatogonium, meiotic division of the spermatocytes, and transformation of the four
resulting spermatids (from each spermatocyte) into spermatozoa (sperm)
Explain about the sperm
Each sperm is made up of three main parts, the head, midpiece (body) and tail.
Head of the sperm contains the haploid nucleus carrying the paternal genetic material. A special
vesicle called the acrosome is present at the anterior end of the head. It contains hydrolytic
enzymes such as trypsin and hyaluronidase that help the sperm to penetrate the outer layers of the
ovum. Midpiece of the sperm contains many mitochondria that provides ATP necessary for the
movement of the tail.
The tail of the sperm contains a long fl agellum with typical 9+2 arrangement of microtubules. It is
produced by the centriole found near the base of the nucleus. The tail enables the sperm to swim
along the female reproductive tract towards an ovum.
What does the semen contain?
Main fraction of
the semen is made up of secretions from seminal vesicles and the prostate gland.
The semen contains several components such as mucus, enzymes, prostaglandins, ascorbic acid,
citrate and fructose which promote the survival of sperm.
What does the semen contain?
Main fraction of the semen is made up of secretions from seminal vesicles and the prostate gland.
The semen contains several components such as mucus, enzymes, prostaglandins, ascorbic acid, citrate and fructose which promote the survival of sperm.
What is the function of the semen?
The semen provides a liquid medium for the sperm movement and also helps to neutralize the acidity in the female reproductive tract.
What kind of fluid does the seminal vesicle produce?
They are a pair of two small pouches that produce a thick, yellowish
fluid that is expelled during ejaculation
What is the function of the seminal fluid?
Seminal fluid is alkaline to protect the sperm in the acidic environment of the vagina.
What does the seminal fluid contain?
mucus, fructose (that provides most of the sperm’s energy), a coagulating enzyme (helps semen coagulates after ejaculation), ascorbic acid and local regulators called prostaglandins.
This fluid contributes to about 60% of the volume of semen.
What does the each seminal vesicle open into?
Each seminal vesicle opens into a short duct that joins the corresponding
vas deference to form an ejaculatory duct.
Where can the prostate gland be found in?
This gland is found below the urinary bladder
What does the prostate gland secrete?
It secretes a thin, milky fluid directly into the urethra through small ducts
What does the prostate gland secretions contain?
This milky secretion contains coagulants,
anticoagulant enzymes and citrate which is a sperm nutrient. This fluid contributes to about
30% of the volume of semen.
What does the pair of bulbourethral gland contain?
They are a pair of small glands found along the urethra below the
prostate.
What does the bulbourethral gland secrete?
These glands secrete a clear alkaline mucus that is able to neutralize any acidic
urine remaining in the urethra and lubricates the lining of the urethra.
Describe the hormonal control of the human male reproductive system.
· In males, in response to the release of GnRH from the hypothalamus (just before puberty),
results in the release of FSH and LH by the anterior pituitary. Rising levels of the FSH and
LH hormones at puberty promotes mature functioning of the male reproductive organs.
The hormones regulate the development, growth, pubertal maturation and reproductive
processes of the body.
· FSH and LH hormones direct spermatogenesis by acting on different types of cells in the
testis.
· FSH stimulates Sertoli cells to nourish the developing sperm.
· LH causes Leydig cells to produce testosterone and other androgens to promote
spermatogenesis.
· Two negative-feedback mechanisms control sex hormone production in males.
· Testosterone inhibits GnRH, FSH and LH in blood through its eff ect on the hypothalamus
and anterior pituitary.
· Additionally inhibin produced by Sertoli cells, acts on anterior pituitary gland to reduce
FSH secretion.
· These negative-feedback circuits maintain testosterone and other androgen levels in the
normal range.
What are the female gonads?
ovaries
What are the steps of human development?
Fertilization/conception and the formation of a human zygote
Cleavage of the zygote, blastocyst formation and implantation
Embryonic members / fetal membranes
Placenta and umbilical cord