Human Behavior Interdependence II Flashcards
Writing about stressful events resulted in improvement in what?
RA and asthma symptoms
How does stress to cold viruses?
you are more susceptible if you are stressed
Psychological stress can affect disease T or F?
T
(blank) is the study of interactions b/w behavior, the nervous system and the immune system.
psychoneuroimmunology (PNI)
What are the components to PNI?
immune system and endocrine effect the brain and nervous system which in turn affect behavior and visa versa.
What three systems are just one integrated system?
immune system, endocrine system, nervous system
What do myeoblasts turn into?
basophils, eosinophils, monocyte, neutrophils
What 2 things can monocytes turn into?
macrophages and dendritic cells
What are the 2 innate defenses?
surface barriers (skin, mucous membranes) internal defenses (phagocytes, fever, NK, antimicrobial proteins, inflammation)
What are the 2 adaptive defenses?
humoral immunity
cellular immunity
Is inflammation prevalent in chronic diseases?
yes!
Experiencing a stressful situation, as perceived by the brain, results in the stimulation of what 2 axes?
hypothalamic-pituitary-adrenal (HPA) and sympathetic adrenal medullary (SAM) axis.
When we are stressed, we release glucocorticoids, where did these come from?
ACTH is released by pituitary gland which results in production of glucocorticoids
The SAM axis can be activated by stimulation of the adrenal medulla to produce the catecholamines (blank and blank) , as well as by ‘hard-wiring’, through sympathetic-nervous-system innervation of lymphoid organs.
adrenaline and noradrenaline
(blank) have receptors for stress hormones that are produced by the pituitary and adrenal glands and can be modulated by binding of these hormones to their respective receptors.
leukocytes
(blank) produced at nerve endings can module immune-cell function by binding its receptor at the surface of cells within lymphoid organs. How is this bidirectional?
noradrenaline
because cytokines produced immune cells can modulate the activity of the hypothalamus.
Classic condition; give an example
pavlovs dog
pavlovs condition of inflammation
T or F
Pavlov conditioned mice to have an inflammatory response in response to saccharin by utilizing LPS to induce an inflammation and using saccharin as the conditioned stimulus
T
What does LPS do?
stimulates liver macrophaes, TNF alph goes from liver to the brain
What does TNF alpha bind to and what does this generate?
binds to hypothalamic cells
releases neurohormnes that generate nerve impulses that influence behavior
i. e., animal studies link (blank) to acute exposure to electric shocks, social defeat, maternal separation, handling, loud noise, and crowding
i. e., human studies link (blank) to final exams, sleep deprivation, divorce, bereavement, Alzheimer caregiving, negative emotions
suppression of immune system
suppression of immune system
Is there a definitive causal link between stress and immunity?
no but many correlations
What could the correlations between stress and immunity be linked to?
mediating variables, such as stress affecting behavior patterns (eating, drinking, social interactions) which then affect immunity
T or F
Stress can delay wound healing
What research proved this?
T
dental students with a wound inflicted healed slower before an exam than on summer vacation
cargivers healed slower than controls