HUBBARD SET

Question 1

substances that are recognized as foreign by the body and therefore elicit immune responses.

Answer 1

Antigens

Question 2

this is where blood group antigens exist

Answer 2

surface of RBCs

Question 3

T/F:

Only a small number of blood group antigens are considered clinically significant

Answer 3

TRUE

Question 4

How many blood group antigens have been described?

Answer 4

more than 600

Question 5

are immunoglobulins developed in response to the presence of antigens

Answer 5

Antibodies

Question 6

are type of antibodies produced in response to antigens from another species

Answer 6

Heterantibodies

Question 7

are type of antibodies formed in response to antigens from individuals of the same species

Answer 7

Alloantibodies

Question 8

are type of antibodies involved in transfusion reactions

Answer 8

Alloantibodies

Question 9

are type of antibodies made in response to the body’s own antigens

Answer 9

Autoantibodies

Question 10

Immunoglobulins are produced and secreted by _______?

Answer 10

Activated B lymphocytes

Question 11

basic structure of immunoglobulins

Answer 11

two light chains & two heavy chains held by disulfide bonds

Question 12

How many classes of immunoglobulins are there?

Answer 12

5

Question 13

Five classes of Immunoglobulins

Answer 13

IgM
IgA
IgG
IgE
IgD

Question 14

Immunoglobulin classes produced against RBC antigens

Answer 14

IgG
IgM
IgA (rarely)

Question 15

Only immunoglobulin class that can cross placental barrier

Answer 15

IgG

Question 16

Immunoglobulin class that occur with IgG and IgM antibodies having the same specificity

Answer 16

IgA

Question 17

Immunoglobulin class that account for the majority of clinically significant antibodies directed against blood group antigens

Answer 17

IgG

Question 18

Immunoglobulin class that do not fix complement

Answer 18

IgA, IgG4

Question 19

Immunoglobulin classes which can cause agglutination in saline

Answer 19

IgA, IgM

Question 20

Number of IgG subclasses

Answer 20

4

Question 21

Subclasses of IgG

Answer 21

IgG1, IgG2, IgG3, IgG4

Question 22

(Most, some) IgG antibodies contain all four subclasses

Answer 22

Most

Question 23

T/F:

Some IgGs are predominantly or exclusively composed of a single subclass

Answer 23

TRUE

Question 24

T/F:

IgG subclasses display different biologic properties

Answer 24

TRUE

Question 25

T/F:

Not all IgG subclasses bind to the crystallizable fragment (Fc) receptors on macrophages

Answer 25

FALSE

ALL IgG subclasses bind to the crystallizable fragment (Fc) receptors on macrophages

Question 26

Which IgG subclass cannot bind complement through classic pathway

Answer 26

IgG4

Question 27

Which IgG subclass/es bind/s complement the least efficienty

Answer 27

IgG2

Question 28

Major IgG subclass, comprising 65% - 70% of total IgG found in serum

Answer 28

IgG1

Question 29

These immunoglobulin class agglutinate VERY STORNGLY in saline

Answer 29

IgM

Question 30

considered complete antibodies

Answer 30

IgM

Question 31

IgM structure

Answer 31

pentamer

Question 32

T/F:

IgM strongly fixes complement through the classic pathway

Answer 32

TRUE

Question 33

term used to refer to agglutination of RBCs

Answer 33

Hemagglutination