HTN Pharmacology

Question 1

How does cGMP cause vasodilation in smooth muscle?

Answer 1

Activates PKG, which phosphorylates MLCK and inactivates it

Question 2

How do arterial vasodilators relax smooth muscle?

Answer 2

Induce NO formation, which activates GC to make more cGMP

Question 3

What is a possible complication of starting a patient on alpha-1 adrenergic blockers?

Answer 3

First dose effect

Question 4

What is “first does effect” with respect to adrenergic blockers?

Answer 4

Orthostatic hypotension, transient dizziness, faintness, palpitations, reflex tachycardia Give first does at bedtime to minimize effects

Question 5

Where are beta-1 receptors located?

Answer 5

Heart and kidney

Question 6

Where are beta-2 receptors located?

Answer 6

Lungs, liver, pancreas, arteriolar smooth muscle

Question 7

What are the effects of beta-1 receptor stimulation?

Answer 7

Increased heart rate, contractility, renin release

Question 8

What are the effects of beta-2 receptor stimulation?

Answer 8

Bronchodilation, vasodilation, insulin secretion

Question 9

Which class of drugs can prevent or regress LV hypertrophy?

Answer 9

ACE inhibitors

Question 10

Which anti-platelet drug is a reversible binder of ADP receptor P2Y12?

Answer 10

Ticagrelor