HTN Drugs Flashcards
Which diuretic induces metabolic acidosis? alkalosis?
acetazolamide: met acidosis
Loop and thiazide diuretics: met alk
Which diuretic induces hypocalcemia?
loop diuretics
- ethacrinic acid!!
- furosemide
- bumetanide
- torsemide
Which diuretic can induce gout attack?
loop diuretic - dehydration
Half life of furosemide
aka La SIX so 4-6 hours
non sulfa containing loop/thiazide?
ethacrinic acid
thiazide side effects
Hypokalemia
Hyperuricemia
Hyperglycemia
metabolic alkalosis
What can make a rock pee?
metalozone
good to use in conjunction with a loop diuretic in pts with CKD
What does spironolactone and epleronone block?
mineralocorticoid receptor
note that amlodipine and triamterine blocks Na channels on the apical side
How can ACE-I increase K+ retention?
it blocks production of aldosterone. which ends up blocking K+ secretion
How do amlodipines and triamterine increase K+ retention?
they block Na+ channels on the apical side. which prevents K+ from exchanging with it and going into the lumen
American Society HTN guideline, which drugs should you treat black pts with first line?
CCB or thiazide
If you use ARBs, what do you see K+ levels becoming?
hyperkalemia
ACEI too
CCBs: List the Dihydropyridines and Non-dyhydros
- which one is a more potent vasodilator?
dihidros: -pines
- amlodipine, felodipine
- more potent VASODILATOR
Nondi:
- verapamil and diltiazem
- CARDIAC DEPRESSIon
Dihydropyridines and Non-dyhydros
- which one is a stronger inhibitor of P450?
NDHP: prevent break down of other drugs, careful
DHP: mild
Minoxidil
very potent vasodilator
- 3 drug drug
