HTN drugs

Question 1

Thiazide diuretic

Answer 1

hydrochlorothiazide

Question 2

Loop diuretic

Answer 2

Furosemide

Question 3

K+ sparing diuretic

Answer 3

spironolactone

Question 4

Cardioselective beta blockers

Answer 4

atenolol

metoprolol

Question 5

Non cardioselective beta blockers

Answer 5

propanolol

nadolol

timolol

Question 6

Mixed alpha and beta blockers

Answer 6

labetolol

carvedilol

Question 7

Name a Ca2+ channel blocker that works on vascular smooth muscle primarily

Answer 7

Nifedipine

DHP-CCB–> DHPs have increased selectivity for vasculature whereas non-DHPs have more selectivity for the heart

Question 8

non-DHP Ca2+ channel blockers (2)

Answer 8

Diltiazem

Verapamil

can cause bradycardia and reflex tachy because work mostly on the heart rather than vasculature

Question 9

which drugs might be affected by grapefruit juice? why?

Answer 9

Ca2+ channel blockers

because they are metabolized by CYP3A4 which is inhibited by grapefruit juice

Question 10

ACEi (4)

Answer 10

Captopril

Ramipril

Enalapril

Perindopril

Question 11

ARBs (1)

Answer 11

Losartan

angiotensin I antagonist thus blocking action of angiotensin II–> downstream of ACEi thus no effect on bradykinin

Question 12

Alpha 1 blockers (3)

Answer 12

Prazocin

Terazocin

Doxazocin

Question 13

Aldsoterone antagonists (2)

Answer 13

spironolactone

eplerenone

Question 14

Name a direct vasodilator

Answer 14

hydralazine

arteriolar smooth muscle selective–no effect on venous smooth muscle//can cause reflex tachy

Question 15

what drug would you use for pregnant women in hypertensive emergencies

Answer 15

hydralazine