HSV

Question 1

What percentage of pregnant women are IgG+ for HSV-2?

Answer 1

20%

13% have both HSV-1 and HSV-2

Question 2

What percentage of women HSV seroconvert during pregnancy?

Answer 2

2-4%

Question 3

What percentage of HSV-2 infected people are not aware of having the infection?

Answer 3

75-90%

Question 4

Symptoms of newly acquired HSV infection

Answer 4

Asymptomatic in 70% of pregnant women

30% - minimal lesions, widespread genital lesions, tender regional lymph node enlargement, fever, malaise, headache

Question 5

HSV-1 causes what percentage of oral infections? genital?

Answer 5

90% oral

10% genital

Question 6

HSV-2 causes what percentage of oral infections? genital?

Answer 6

10% oral
90% genital
(but among college-age populations, majority of new cases of genital HSV are HSV-1)

Question 7

What percentage of neonatal HSV results from women who acquire HSV-1 or -2 near term?

Answer 7

50-80%

Question 8

What is a “nonprimary first-episode HSV infection

Answer 8

HSV-2 confirmed in a person with prior HSV-1, or vice-versa. Symptoma sare usually milder than a first-episode primary infection.

Question 9

What is reactivation (recurrent) genital herpes?

Answer 9

• Caused by reactivation of latent HSV, usually HSV-2.
• Over 90% of HSV episodes in pregnancy are recurrent or nonprimary 1st
• Symptoms last 7-10 days, with low viral load shedding for 3-5 days.

Question 10

What is the incidence of neonatal HSV after a vaginal delivery during a first episode primary infection?

Answer 10

25-50%

Question 11

What is the incidence of neonatal HSV after a vaginal delivery during a recurrent infection?

Answer 11

<1%

Question 12

Why is the incidence of neonatal HSV after a primary maternal infection higher?

Answer 12

The infant of the mother with primary HSV lacks the protection of transplacental type-specific antibodies. The major sites of intrapartum viral entry are the neonatal eys, nasopharynx, or a break in the skin. Transplacental infection is rare.