HSR Flashcards
1
Q
What mediates 1 - 3? 4?
A
1 - 3: Ig
4: Cell
2
Q
What are the 4 types?
A
ACID I: Allergic II: Cytotoxic III: Immune complex IV: Delayed
3
Q
What Happens in type I?
A
“Allergic” Acid
1. TH2 releases IL4/5 = IgM class switches to IgE
2. IgE on mast cell will now degranulate with 2nd antigen exposure
3.
4
Q
Bea sting?
A
HSR 1
5
Q
Peanut?
A
HSR 1
6
Q
Asthma?
A
HSR 1
7
Q
Rhinitis?
A
HSR 1
8
Q
Eczema?
A
HSR 1
9
Q
What happens in type II?
A
“Cytotoxic” aCid
- IgM/G activate complement
- C5a call in neuts and dilates
- Opsonization
- Neutralization
10
Q
What happens in type III?
A
“acId” Immune complex
1. IC getting stuck in tissues leading to activation of complement pathway
11
Q
Serum sickness?
A
Type III
12
Q
Type IV?
A
“aciD” Delayed
13
Q
Transplant rejection
A
IV
14
Q
Poison Ivy?
A
IV -IVy
15
Q
Anaphylaxis?
A
I
16
Q
Localized autoimmune?
A
II
17
Q
Rheumatic fever?
A
Type II
18
Q
Lupes?
A
III
19
Q
RA?
A
III
20
Q
Systemic autoimmune?
A
III
21
Q
Hashimoto?
A
IV
22
Q
Graves?
A
II
23
Q
Febrile non hemolytic transfusion rxn?
A
II
24
Q
Anti ccp?
A
RA
25
Q
Acute rejection?
A
IV - weeks after so is delayed
