HRQOL Flashcards
Disease-Specific Measures
employed to gather more focused insights
into the impact of a particular condition on patient
Examples of disease-specific instruments
Diabetes-Specific QoL Instrument (DQOL)
functional Assessment of Cancer Therapy (FACT)
Clinically Developed Psychosocial Assessment (CDPA)
what are Range of scores of hrqol?
Each instrument gives multiple scores per respondent.
Each instrument has a different ranges or scoring
Health Status Surveys: which hrqol measure chose for this?
Generic measures: valuable in surveys aiming to document the spectrum of disability within a general population or a specific patient group.
which hrqol measure chose for Clinical Trials
disease-specific measures, When studying a new therapy plan or drug
HRQoL instruments 4 domains
- Physical functioning
- Psychological functioning
- Social and role functioning
- General health perceptions
Physical Functioning
capture information on the observable limitations or disability experienced by the patient over a defined period of time.
Psychological (Mental) Functioning
refers to psychological distress that can be the consequence of a disease or a side effect of a treatment
Social or Role Functioning
involves building and maintaining social relationships, addressing both
interaction participation and satisfaction
General Health Perception
Includes questions that prompt patients to express their overall beliefs and evaluations regarding their health.
These questions cover both current health status and future health expectations.
instruments for generic measure
Medical Outcomes Study Short-Form (MOS) includes SF-36 and SF-12
▪ Quality of Well-Being (QWB) Scale
▪ Sickness Impact Profile (SIP)
Medical Outcomes Study Short-Form Survey
multipurpose survey for assessing generic health status.
SF-36 : eight health-related concepts for physical and mental health.
self-evaluation of change in health.
SF-36 is valuable for comparing the relative burden of different diseases.
advantages of general measure
broadly applicable
sumarize range of concepts
detect anticipated effects
disadvantages of disease specific
less likely to detect unanticipated effects
cannot compare cross population
advantages of disease specific
more relevant to specific population
more responsive to change in health
disadvantages of general measure
not relevant to specific population
not responsive to change in health
results difficult to interpret
HRQoL Challenges
Using multidimensional health status measures
outcome measurement involves multiple scores, each representing different aspects of the disease.
complicates the interpretation, making it more challenging to integrate such results into pharmacoeconomic assessments.
HRQoL Measures
Termed non-utility or non-preference measures
HRQoL Measures points
self-assessment of their health at a
specific moment.
patient’s perspective,directly or through proxies
surveys are multidimensional
QoL
Encompasses health and non-health aspects (e.g., economic).
Broad concept measuring overall life perception.
QoL versus HRQoL
Focuses on the functional impact of illness and treatment.
Represents a subset of an individual’s overall QoL.
HRQoL definition
HRQoL represents the functional effect of an illness and its consequent therapy upon a patient, as perceived by the patient.
