HRQOL

Question 1

Disease-Specific Measures

Answer 1

employed to gather more focused insights
into the impact of a particular condition on patient

Question 2

Examples of disease-specific instruments

Answer 2

Diabetes-Specific QoL Instrument (DQOL)
functional Assessment of Cancer Therapy (FACT)
Clinically Developed Psychosocial Assessment (CDPA)

Question 3

what are Range of scores of hrqol?

Answer 3

Each instrument gives multiple scores per respondent.
Each instrument has a different ranges or scoring

Question 4

Health Status Surveys: which hrqol measure chose for this?

Answer 4

Generic measures: valuable in surveys aiming to document the spectrum of disability within a general population or a specific patient group.

Question 5

which hrqol measure chose for Clinical Trials

Answer 5

disease-specific measures, When studying a new therapy plan or drug

Question 6

HRQoL instruments 4 domains

Answer 6

1. Physical functioning
2. Psychological functioning
3. Social and role functioning
4. General health perceptions

Question 7

Physical Functioning

Answer 7

capture information on the observable limitations or disability experienced by the patient over a defined period of time.

Question 8

Psychological (Mental) Functioning

Answer 8

refers to psychological distress that can be the consequence of a disease or a side effect of a treatment

Question 9

Social or Role Functioning

Answer 9

involves building and maintaining social relationships, addressing both
interaction participation and satisfaction

Question 10

General Health Perception

Answer 10

Includes questions that prompt patients to express their overall beliefs and evaluations regarding their health.
These questions cover both current health status and future health expectations.

Question 11

instruments for generic measure

Answer 11

Medical Outcomes Study Short-Form (MOS) includes SF-36 and SF-12
▪ Quality of Well-Being (QWB) Scale
▪ Sickness Impact Profile (SIP)

Question 12

Medical Outcomes Study Short-Form Survey

Answer 12

multipurpose survey for assessing generic health status.
SF-36 : eight health-related concepts for physical and mental health.
self-evaluation of change in health.
SF-36 is valuable for comparing the relative burden of different diseases.

Question 13

advantages of general measure

Answer 13

broadly applicable
sumarize range of concepts
detect anticipated effects

Question 14

disadvantages of disease specific

Answer 14

less likely to detect unanticipated effects
cannot compare cross population

Question 15

advantages of disease specific

Answer 15

more relevant to specific population
more responsive to change in health

Question 16

disadvantages of general measure

Answer 16

not relevant to specific population
not responsive to change in health
results difficult to interpret

Question 17

HRQoL Challenges

Answer 17

Using multidimensional health status measures
outcome measurement involves multiple scores, each representing different aspects of the disease.
complicates the interpretation, making it more challenging to integrate such results into pharmacoeconomic assessments.

Question 18

HRQoL Measures

Answer 18

Termed non-utility or non-preference measures

Question 19

HRQoL Measures points

Answer 19

self-assessment of their health at a
specific moment.
patient’s perspective,directly or through proxies
surveys are multidimensional

Question 20

QoL

Answer 20

Encompasses health and non-health aspects (e.g., economic).
Broad concept measuring overall life perception.

Question 21

QoL versus HRQoL

Answer 21

Focuses on the functional impact of illness and treatment.
Represents a subset of an individual’s overall QoL.

Question 22

HRQoL definition

Answer 22

HRQoL represents the functional effect of an illness and its consequent therapy upon a patient, as perceived by the patient.