H.pylori Flashcards

1
Q

What is H.pylori?

How does it cause gastric ulcers?

A

Gram negative bacillus
Causes a persistent immune reaction –> inflammation in the stomach.
Decreases the activity of Somatostatin producing D-cells –> results in increase relate of Gastri –> gastric acid causes gastric ulcer

(ref etg)

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2
Q

What is the life time risk of gastric ulcers with h.pylori?

A

10%

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3
Q

What are alarm symptoms?

A

anemia, bleeding, weight loss, dysphagia (ref etg)

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4
Q

When should h.pylori be tested?

A

epigastric pain & dyspepsia
Fhx of gastric ca
screen patients undergoing NSAID therapy (ref etg)

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5
Q

Urea Breath Test:
1/ how long should you stop antibiotic therapy and PPI?

2/ how does it work?

3/ what is the radiation like?

4/ is it suitable for children?

A

1/ Antibiotic therapy and bismuth should not be taken for 4/52, PPI withheld for atleast for 1/52 (preferably for 2 weeks)

2/ hpylori has enzyme urease which breaks down urea
Urea with a with a radioisotope is swallowed –> blown out as carbon dioxide if H.pylori present

3/ 1/10th dose of CXR, 1/2 normal daily background radiation

4/ suitable for >6years of age.

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6
Q

In Australia what’s the prevalance of H.pylori?

A

30% (Ref: h.pylori eradication, an update on the latest therapies)

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7
Q

When should h.pylori related peptic ulcer be considered in patients?

A

with epigastric pain or dyspepsia

(Ref: h.pylori eradication, an update on the latest therapies)

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