HPV vaccination

Question 1

For girls and boys who receive their first dose of HPV vaccine before 15 years of age, only two doses are needed. The timing of the two doses is 0 (baseline) and 6–12 months. If the interval between the two doses is less than 5 months, a third dose is recommended. If females or males receive their first dose at 15 years of age or older, three doses are needed and given at 0 (baseline), 1–2 months after the first dose, and 6 months after the first dose.

Answer 1

HPV vaccine <15 years only 2 doses needed.
0, then 6-12 months later

if interval btwn the two doses is < 5 mths, then 3rd dose is recommended.

if receive > 15, then need 3 doses
1, 1-2 months after 1st dose, then 6 months after 1st dose

Question 2

Of the more than 150 HPV genotypes, 13 genotypes have been shown to cause cervical cancer (1). Most cases of HPV-associated cancer are caused by HPV genotypes 16 and 18 (2–5). In the United States, HPV genotypes 16 and 18 account for 66% of cases of cervical cancer, and HPV genotypes 31, 33, 45, 52, and 58 account for an additional 15% of cases of cervical cancer (5). For cervical intraepithelial neoplasia 2+, 50–60% of cases are caused by HPV genotypes 16 and 18, and 25% of cases are caused by HPV genotypes 31, 33, 45, 52, and 58 (6). Approximately 90% of cases of genital warts are caused by HPV genotypes 6 and 11 (7).

Answer 2

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Question 3

Additionally, HPV vaccination may decrease the incidence of oropharyngeal cancer as well as the maternal transmittal of HPV to infants. Human papillomavirus in infants may result in recurrent laryngeal papillomatosis, although definitive prevention trials have not been completed for these two disease endpoints

Answer 3

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