HPV

Question 1

Structure of HPV

Answer 1

Ds DNA , 50-55nm diameter, small, non enveloped, icosahedral containing
72 capsomeres and
8000 nucleotides base pairs encoding
9 overlapping genes

Question 2

Genome of HPV is divided in to?

Answer 2

Regulatory, Early and Late genes

Question 3

Function of regulatory gene of HPV

Answer 3

Regulatory gene does not encode protein but regulates expression and replication

Question 4

Function of E Protien of HPV

Answer 4

E protien necessary for regulation of DNA replication but not incorporated in the viral particle

• E6 protein: inactivates cells Tumor suppressesor protein p53
• E7: inhibits rb protein which regulates cell cycle proliferation

Question 5

Function of L gene of HPV

Answer 5

L protein s form the outer protein shell or capsid of HPV

• mainly L1 L2
• HPV subtypes are based on sequence of L 1 region

Question 6

Common plantar warts types

Palmoplantar warts

Answer 6

• 1,2,4,27,57
• 1,2,4,27,57,29

1: deep plantar
2: mosaic warts

Question 7

Flat warts

Answer 7

3,10,28,49

Question 8

Butchers warts

Answer 8

7

Question 9

EDV

Answer 9

3,5,8

Question 10

Condyloma acuminata

Answer 10

16,18,31,33,51

Question 11

Bushke lowenstein tumor

High grade in and cervical ca

Answer 11

6,11

6,11,16,18

Question 12

Heck’s disease (focal epilthelial hyperplasia)

Answer 12

13,32

Question 13

Bowenoid papulosis

Answer 13

16

Question 14

Podophyllotoxin percentage and mode of application

Answer 14

0. 5% in ethanol
   - less than 10cm2 area at a time and less than 0.5ml each day
   - self application
   - two times a day for 3 days and 4 consecutive days off period
   - done for a mnth

Question 15

Podophyllin percentage and mode of application

Answer 15

25% solution in compound tincture of benzoin

- applies for 4 hrs under medical supervision weekly interval

Question 16

MOA of podophyllin

Answer 16

Disruption of mitotic spindles