HPV Flashcards
1
Q
HPV - overview
A
- Double-stranded DNA virus. Over 200 subtypes known to infect humans; 40 cause anogenital infection. 80% of sexually active adults will have been exposed to at least one of the anogenital strains, although most are subclinical (and therefore unrecognised). Condom use reduces the risk of transmission but does not offer complete protection
- Some HBV subtypes cause a local epithelial reaction, which results in a visible papilloma or wart. Genital warts may be single or multiple, and vary greatly in size and colour
- Immunosuppression and pregnancy are often associated with persistent, larger and more numerous warts
- HPV subtypes 6 and 11 cause 90% of clinical warts in the genital region. These subtypes almost always regress spontaneously over time and are not associated with neoplastic change
- Tx usually for cosmetic reasons, although occasionally they may itch or bleed. Local application of podophyllotoxin, 5-fluorouracil, imiquimod (all contraindicated during pregnancy), trichloroacetic acid. Physical destruction of warts is also an option - cryotherapy (most common technique in Australia), cautery, laser, excision. Regardless of tx modality, recurrence rates are high (esp in first 3-6mo after tx)
