HPM Questions Flashcards
What are the components of Total Pain?
Physical, Psychological, Social, and Spiritual
What is acute pain?
Occurs suddenly due to illness, injury, or surgery, that is generally short-lived that resolves as the acute illness heals
What is chronic pain?
Pain that lasts longer than the expected healing process (3 months for IASP), and that affects a person’s activities of daily living
What is nociceptive pain?
Arises from actual or threatened damage to non-neural tissues due to activation of nociceptors
What are common symptoms of somatic nociceptive pain?
Arises from bone, joint, muscle, skin, or connective tissue that is well-localized, aching, and throbbing
What are common cymptoms of visceral nociceptive pain?
Arsises from visceral organs (such as the GI tract), that is aching if related to capsular pain or poorly localized cramping if due to hollow viscus organ pain
What are the stages of nociceptive pain?
Transduction -> Conduction -> Transmission -> Perception -> Modulation
What are the characteristics of pain conducted by C-fibers?
C-fibers are small, unmyelinated, slow-conducting fibers that transmit dull, poorly localized, diffuse, burning/aching pain, and are sensitive to mechanical, thermal, or chemical stimuli
What are the characteristics of pain conducted by A-delta fibers?
A-delta fibers are large, myelinated, fast-conducting fibers that transmit well-localized, sharp pain, and are sensitive to mechanical and thermal stimuli
What are the characteristics of pain conducted by A-beta fibers?
A-beta fibers conduct non-noxious input (i.e., touch), and do not transmit pain signals
Which of the stages of nociceptive pain is not responsive to drug therapy?
Perception
What is an example of transduction of pain?
Nociceptors translate physical stimulus into an electrical signal and action potential
What is an example of conduction of pain?
Pain impulse traveling up or up to the spinal cord
What is an example of transmission of pain?
Transfer of an action potential from one neuron to the next
What is an example of perception of pain?
The conscious experience of pain
What is an example of modulation of pain?
Inhibiting descending pain impulses
What medications help reduce the transduction of pain signals?
NSAIDs, anticonvulsants, Capsaicin, Lidocaine, and TCAs
What medications help reduce the conduction/transmission of pain signals?
Opioids (endogenous and exogenous), Gabapentin, Pregabalin, Ketamine, and anticonvulsants
What medications help reduce the perception of pain signals?
None
What interventions help reduce the perception of pain signals?
Relaxation and guided imagery
What medications help reduce modulation of pain signals?
Opioids, Tramadol, Tapentadol, TCAs, SNRIs, and Baclofen
What processes lead to the development of neuropathic pain?
Abnormal nerve regeneration, increased expression of membrane sodium channels, disinhibition of the modulatory process, or decreased expression of mu-opioid receptors
What is allodynia?
Pain from a non-painful stimulus, such as touch
What pain assessment tool has been validated for patients with advanced dementia?
PAINAD – a 5 item observational tool
How long must pain be present in a day for it to be classified as persistent pain?
12 out of 24 hours in a day
What is the preferred route of administration for medications for most patients?
Oral
What are the FDA guidelines to starting transdermal Fentanyl in patients?
Patients must be receiving and tolerating at least 60mg of oral Morphine equivalents per day for no less than 7 days (1 week)
What is the maximum daily dose of Acetaminophen recommended by the FDA?
4 grams
What opiate should you avoid due to it being a strong CNS irritant with dysphoria, irritability, tremors, myoclonus, and seizures?
Meperidine (Demerol)
If a patient has a neurolytic procedure performed, when might they have return of pain sensation secondary to nerve regeneration?
3 to 6 months
What kind of nerve blocks help with visceral pain?
Sympathetic nerve blocks
What kind of nerve blocks help with focal pain?
Somatic nerve blocks
What are the main types of sympathetic nerve blocks?
Celiac plexus Lumbar Superior hypogastric Stellate ganglion Ganglion impars
What are the main types of somatic blocks?
Brachial plexus
Gasserian
Paravertebral
Epidural/Intrathecal
What is the indication for a superior hypogastric plexus block?
Visceral pelvic pain that is refractory to medical management
For what cancer type is a neurolytic procedure a first-line therapy for pain?
Upper abdominal cancers (i.e., pancreatic cancer)
What neurolytic intervention is indicated for pancreatic cancer?
Celiac plexus block
What are the side effects associated with a celiac plexus block?
Orthostasis and diarrhea
What kind of nerve block is indicated for chest wall pain (e.g., breast cancer pain or rib metastases)?
Intercostal
What kind of nerve block is indicated for unilateral leg pain?
Lumbar subarachnoid
What is another kind of nerve block indicated for pelvic pain?
Phenol saddle
What is another kind of nerve block indicated for chronic pelvic pain (e.g., interstitial cystitis)?
Pudendal nerve
What is complex regional pain syndrome?
Regional pain that is associated with focal autonomic dysfunction
What kind of nerve block is indicated for spinal facet joint pain (e.g., malignant vertebral compression fractures)?
Medial branch of the primary dorsal ramus
When are nerve blocks for trigeminal neuralgia indicated?
As a last resort
What nerve block has the lowest risk for adverse effects when treating
Gasserian ganglion block
What is the life expectancy patients should generally have if they are being referred for an epidural catheter for pain management?
Days to weeks
What is a major risk of epidural catheter placement?
Catheter fibrosis
What is the life expectancy patients should generally have if they are being referred for an intrathecal catheter for pain management?
Weeks to months
How much oral morphine daily dose equivalents must a patient be taking before being referred for an intrathecal catheter for pain management?
Greater than or equal to 100mg
What medications can be used in neuraxial pain management?
Opiates - Morphine, Hydromorphone, Fentanyl
Non-Opiates - Bupivacaine, Clonidine, Ziconotide, Baclofen
What are the common side effects seen with Bupivacaine neuraxial pain management?
Urinary retention, paresthesias, lower extremity weakness, gait impairment, and orthostatic hypotension
What is the most common side effect seen with Ziconotide neuraxial pain management?
Psychosis
What is the most emergent complication of an intrathecal pain pump?
Spinal cord and/or nerve injury
What are common non-emergent complications of intrathecal pain pumps?
CSF leaks, infection, migration, release of large concentrations of drug, and/or granulomas
What are the conversion ratios for Morphine?
PO = 30mg IV = 10mg Epidural = 1mg Intrathecal = 0.1mg
What are the conversion ratios for Hydromorphone?
PO = 7.5mg IV = 1.5mg Epidural = 0.2mg Intrathecal = 0.04mg
What are the conversion ratios for Fentanyl?
IV = 100mcg Epidural = 33mcg Intrathecal = 6-10mcg
When are vertebroplasty and/or kyphoplasty indicated?
Used for symptomatic compression fractures to reduce pain and stabilize the fracture, most often showing pain relief in cancer patients
What are the contraindications to vertebroplasty and/or kyphoplasty?
- ) Epidural disease
- ) Neurologic damage related to the fracture
- ) Fracture with bone fragments extending into the spinal cord
- ) Infection
- ) Hypercoagulable state
- ) Severe cardiopulmonary disease
How long after radiation therapy do patients typically experience pain relief?
2 to 4 weeks
What is a rhizotomy?
A surgical procedure to sever the nerve roots of a spinal cord
What is a cordotomy?
A surgical procedure that disables selected pain-conducting tracts in the spinal cord to achieve pain control
When is a cordotomy indicated?
Severe, uncontrolled, refractory cancer pain
What is the primary use for Ketamine?
Refractory neuropathic pain
What is a growing use for Ketamine?
Refractory depression
What are the most common side effects of Ketamine?
Vivid dreams, hallucinations, floating sensations, and visual-spatial disorders
What is a rare side effect seen with Ketamine abuse?
Ulcerative cystitis
What medication should you use if there are psychogenic side effects seen while administering Ketamine?
Lorazepam
What is the preferred steroid to use in cancer pain management?
Dexamethasone
Why is Dexamethasone the preferred steroid to use in cancer pain?
Low mineralocorticoid effect
Other than pain, when might a provider consider steroids for symptom control?
End-of-life fatigue, anorexia, and nausea
What is the primary indication for topical lidocaine?
Post-herpetic neuralgia
For which disease processes has acupuncture been shown to have promising benefits?
Chemotherapy-induced neuropathy and post-thoracotomy pain
Which pain disease state does Cognitive Behavioral Therapy best treat?
Chronic pain
What are known contraindications for acupuncture?
An active infection or known malignancy at the site of needle insertion
What are the known indications for St. John’s Wort?
Depression and auto-inflammation
What are the side effects of St. John’s Wort?
- ) Interferes with the metabolism of opiates
- ) Blood thinner
- ) Increased risk of serotonin syndrome
What drug is ginger known to interact with?
Coumadin (Warfarin)
What is the most prevalent symptom in palliative care?
Fatigue
What is the definition of fatigue?
Extreme tiredness, typically resulting from mental/physical exertion
What other diagnoses should be considered when patients present with fatigue?
Depression, hypoactive delirium, weakness, or demoralization
What has been shown to improve cancer-related fatigue in particular individuals?
Exercise
What is the most likely cause of cancer-related fatigue?
Elevation of pro-inflammatory cytokines such as TNF-alpha, IL-1, and IL-6
What are common risk factors for cancer-related fatigue?
Unmarried, lower household income, medical comorbidities, poor nutritional issues, deconditioning, polypharmacy
What two factors are not consistently associated with cancer-related fatigue?
- ) Type of treatment
2. ) Dose intensity
What is the dosing for Methylphenidate for cancer-related fatigue?
Start at 5mg BID
Max of 40mg/day
What is the dosing for Modafinil for cancer-related fatigue?
200mg/day
What is the dosing for Dexamethasone for cancer-related fatigue?
8mg, typically divided into BID dosing
This is the medication of choice for fatigue at end-of-life
What patients are candidates for testosterone supplementation for fatigue?
HIV, ESRD, and COPD
What are the side effects for Megestrol?
Edema, thromboembolic events, increased mortality
What is a known independent risk factor for mortality?
Delirium
How often can delirium be reversed?
50%
What are the symptoms of hypoactive delirium?
Psychomotor retardation
Withdrawal/Apathy
Inattentive
Lethargy
What are the symptoms of hyperactive delirium?
Psychomotor agitation
Aggression
Hypervigilance
Sympathetic hyperactivity
What is the key difference between delirium and dementia?
Attention is impaired in delirium whereas it the patient is confused but does not have impaired attention in dementia
What are life-threatening causes of delirium?
Hypoxia, hyperglycemia, hypertension, Wernicke’s encephalopathy, intracranial hemorrhage, meningitis/encephalitis, or poisoning
What is a severe side effect of antipsychotics used to treat delirium?
Neuroleptic malignant syndrome
What is the FDA Black Box Warning for antipsychotics used to treat delirium?
Sudden death in elderly patients with dementia
What is the first-line therapy for delirium?
Medical evaluation leading to treating the underlying cause
What is a strong contraindication for using Haloperidol?
QTc above 450msec, or if it increases by 25% while on Haloperidol
What antipsychotics are known to potentiate delirium through their anticholinergic side effects?
Chlorpromazine and Olanzapine
What is the safest antipsychotic to use in patients with Lewy-body dementia?
Quetiapine
What are the symptoms associated with xerostomia?
Malodorous breath, altered taste, difficulty chewing/swallowing, tooth decay, gum disease
When should you use sialagogues for patients with xerostomia?
If prognosis is greater than 3 to 6 months
What is a common under-reported cause of insomnia?
Restless leg syndrome
What is the first-line therapy for the treatment of insomnia?
Behavioral therapy
What are the CDC recommendations for the treatment of insomnia?
- ) Consistent bed time
- ) Quiet, dark, relaxing bedroom
- ) No electronic media devices
- ) No meals or alcohol before bed
- ) Exercise during the day
What medications used commonly for insomnia cause an increased risk for accidental opiate overdose?
Zolpidem (Ambien)
What is the first-line therapy for opioid-induced pruritis?
Rotation
What is the second-line therapy for opioid-induced pruritis?
Sertraline, Paroxetine, or Mirtazapine
What is the treatment of choice for opioid-induced pruritis secondary to neuraxially-administered opiates?
Ondansetron
What are effective medications for pruritis associated with HIV?
Indomethicin
Doxepin
What are effective medications for pruritis associated with chronic kidney disease?
Gabapentin
Pregabalin
Mirtazapine
Dronabinol
What are effective medications for pruritis associated with hepatic disease?
Rifampin
Sertraline
Mirtazapine
Dronabinol
What are effective medications for pruritis associated with inflammatory dermatoses?
Steroids
Immunosuppressants
What are the characteristics of a stage I wound?
Intact skin with non-blanchable redness of a localized area, usually over a bony prominence
What are the characteristics of a stage II wound?
Partial thickness loss of dermis presenting as a shallow open ulcer with a red/pink wound bed without sloughing
What are the characteristics of a stage III wound?
Full thickness tissue loss, with visible subcutaneous fat but nonvisible bone/tendon/muscle
What are the characteristics of a stage IV wound?
Full thickness tissue loss with exposed bone/tendon/muscle
Generally, what should the maximum PPS level be for patients who are referred for hospice (or declared terminal)?
30%
What are the PPS breakdowns for ambulation?
80-100% - full 60-70% - reduced 40-50% - mainly site/lie 10-30% - totally bed bound 0% - death
What are the PPS breakdowns for activity and evidence of disease?
100% - normal activity with no evidence of disease
90% - normal activity with some evidence of disease
80% - normal activity with effort
70% - abnormal work with significant disease
60% - unable to house work
50% - unable to any work
40% - unable to most activity
10-30% - unable to do any activity
0% - death
What are the PPS breakdowns for self-care?
70-100% - full 60% - occasional assistance needed 50% - considerable assistance needed 40% - mainly assistance 10-30% - total care 0% - death
What are the PPS breakdowns for intake?
90-100% - normal 30-80% - normal or reduced 20% - minimal to sips 10% - mouth care only 0% - death
What are the PPS breakdowns for conscious level?
70-100% - full
50-60% - full or confusion
20-50% - full or drowsy with or without confusion
10% - drowsy or coma with or without confusion
0% - death
What time period is defined as the active phase of dying?
48 hours prior to death
What are the findings seen in the early stages of dying?
Bed bound Loss of interest and ability in drinking/eating Cognitive changes Increased sedation Delirium
What are the findings seen in the late stages of dying?
Loss of swallowing reflex Death rattle Coma Fever Altered respiratory pattern Skin color changes
What is the chance of CPR survival to ultimate discharge in terminally ill patients?
0%
What medication is the first-choice for hyperactive terminal delirium?
Benzodiazepines such as Lorazepam or Midazolam
What is the first line treatment for death rattle?
Repositioning
How long until death is likely in a fair-skinned patient who develops lower extremity mottling at the end of life?
Hours