How to make a brain

Question 1

What 4 bits are in adult brain?

Answer 1

Cerebral Hemispheres
Diencephalon
Brainstem
Cerebellum

Question 2

How to make adult CNS?

Answer 2

Start w lil patch of ectoderm as a neural plate, which then forms a tube via neurulation from notochord. Caudal and rostral neuropore then close.

Then you get three swellings that form forebrain, midbrain and hindbrain (Prosencephalon, mesencephalon and rhombencephalon). Through differential growth cerebral hemispheres form C shape. Rhombencephalon develops into mesencephalon and myelencephalon

Question 3

The cerebral hemispheres grow differentially in a C shape right. What poor fucks (major structures) do they drag along?

Answer 3

Corpus callosum, fornix, hippocampus, LV

Question 4

Where is fornix?

Answer 4

Medial to superior LV

Question 5

Where is hippocampus?

Answer 5

Medial to LV

Question 6

Where is caudate nucleus?

Answer 6

Lateral to LV

Question 7

Going in a horizontal plane, what structures will you encounter moving lateral to medial at level of 3rd ventricle?

Answer 7

Lateral sulcus, lentiform nucleus (putamen and globus pallidus), internal capsule, thalamus, 3rd ventricle

Question 8

What makes up important basal nuclei?

Answer 8

Putamen, caudate nucleus, thalamus, amygdala (at end of caudate nucleus)

Question 9

How does sensory grey matter in the brainstem move in development?

Answer 9

From dorsal to lareral

Question 10

Where does the cerebellum develop?

Answer 10

In dorsal wall of neural tube

Question 11

What forms dorsal root of spinal cord?

Answer 11

Ingrowth of neuritis from DRG

Question 12

What forms ventral root of spinal cord?

Answer 12

Outgrowth from motor grey neurons

Question 13

What stops everything being neurons?

Answer 13

Bone morphogenic protein BMP

Inhibited bt chordin etc

Question 14

What does defective neural crest development result in?

Answer 14

Stuff like Waardenburg’s and Treacher Collins syndromes