How Muscle Fibers Contract- HOW NERVES CAUSE MUSCULAR CONTRACTION - Trouble at the Synapse!

Question 1

What is Spastic paralysis?

Answer 1

The muscles can’t relax.

Question 2

What is the Effect of Nerve Gas & Insecticides

Answer 2

Spastic paralysis

Question 3

They interfere with the enzyme
AChE, which means it has trouble breaking down ACh.
Because of this, ACh remains in the synapse for too long.

Answer 3

Cholinesterase Inhibitors

Question 4

What is the Effect of Curare?

Answer 4

Flaccid paralysis

Question 5

What is the result of Cholinesterase Inhibitors?

Answer 5

Constant stream of action potentials which keeps the

muscle in a long, sustained contraction.

Question 6

What does Black Widow Venom cause?

Answer 6

Spastic Paralysis with painful cramping where bitten.

Question 7

Botox is a type of curare what is does it do?

Answer 7

It is a botulism toxin. It blocks release of acetylcholine from nerve and causes flaccid paralysis.

Question 8

How does Curare cause flaccid paralysis?

Answer 8

• Binds to ACh receptors, keeping them closed
• Result: Sodium cannot enter muscle cell, so no action potentials
  are created. The muscle is unable to contract.

Question 9

What does Myasthenia Gravis (MG) cause?

Answer 9

Flaccid paralysis

Question 10

How does Myasthenia Gravis (MG) treat Flaccid Paralysis?

Answer 10

It uses cholinesterase inhibitors since they allow ACH to stay in synapse longer.

Question 11

What is Myasthenia Gravis (MG)?

Answer 11

• Autoimmune disease: WBC’s destroy ACh receptors over time
• Result: Sodium cannot enter muscle cell, so no action potentials
  are created. The muscle is unable to contract.