Hotseat Questions Exam 1

Question 1

linear kinetics: if dose is higher, Vd will ____

Answer 1

not change

Question 2

linear kinetics: auc is proportional to dose (T/F)

Answer 2

true

Question 3

linear kinetics: as time passes after drug administration, CL, k, or Vd will ____

Answer 3

not change

Question 4

ionized compounds show poorer membrane permeability than un-ionized compounds (T/F)

Answer 4

true

Question 5

lipophillic compounds tend to show greater membrane permeability (T/F)

Answer 5

true

Question 6

lipophillic compounds tend to show permeability rate limited distribution (T/F)

Answer 6

false

Question 7

decreased plasma protein binding of high protein bound drugs will likely increase Vd (T/F)

Answer 7

true

Question 8

Vd is expected to be small for a drug that exhibits strong binding to tissue components (T/F)

Answer 8

false

Question 9

the time to reach the steady state depends on the dose (T/F)

Answer 9

false

Question 10

doubling the dose will double the steady state concentration (T/F)

Answer 10

true

Question 11

doubling the dose will shorten the time to reach a steady state (T/F)

Answer 11

false

Question 12

kupffer cells are the primary cells in the liver responsible for drug metabolism (T/F)

Answer 12

false, hepatocytes

Question 13

choose two main drug metabolism reactions in the liver:
reduction, oxidation, hydrolysis, conjugation

Answer 13

oxidation and conjugation

Question 14

among cp450 enzymes cyp3a4 metabolizes the largest fraction of drugs (T/F)

Answer 14

true

Question 15

the portal triad consists of the portal vein, bile duct, and central vein (T/F)

Answer 15

false, hepatic arterty

Question 16

enzyme inducers of CYP3A4 would decrease the systemic exposure of CYP3A4 substrates (T/F)

Answer 16

true

Question 17

enzyme inhibitors of CYP3A4 would increase the systemic exposure of CYP3A4 substrates (T/F)

Answer 17

true

Question 18

drugs that are poorly absorbed from the intestine are expected to show low F values (T/F)

Answer 18

true

Question 19

drugs that experience significant first pass effect are expected to have low F values (T/F)

Answer 19

true

Question 20

when a drug is distributed mainly from plasma, Vd estimated from blood concentration is larger than that from plasma concentration (T/F)

Answer 20

true

Question 21

after oral administration of 1g drug, you obtain plasma drug concentration vs. time, you can estimate AUC from curve, using the data you can calculate CL (T/F)

Answer 21

false, you need IV data not oral

Question 22

for a low Eh drug, which of Qh, fu, CLint does rifampin induce and in which direction?

Answer 22

increase CL int

Question 23

warfarin’s fe = 0, what is the relationship between CL and CLH?

Answer 23

they are equal

Question 24

assumming rifampin does not affect Vd of warfarin, what is the effect of rifampin on warfarin t 1/2?

Answer 24

decrease half life

Question 25

name high and low Eh drugs on the above figure in physiological settings.

Answer 25

propanolol is a high Eh

Question 26

name low and high Eh drugs on above figure

Answer 26

anitpyrine is low Eh

Question 27

which of Qh, fu, CL int does a beta blocker influence?

Answer 27

Qh, decrease

Question 28

what would the use of beta blockers do to CLh of a low Eh drug

Answer 28

none