Hormones and RNA interferance Flashcards
OESTROGEN
O is lipid soluble and diffuses across cell surface membrane
An Inhibitor molecule blocks the site that binds to DNA
O binds to receptor
O causes receptor to change shape and release the inhibitor
transcription factor binds with DNA and begins process of transcription
Oestrogen increases gene expression
siRNA
An enzyme cuts large double stranded molecules if RNA into smaller sections of siRNA
One of the siRNA strands combines with an enzyme
The base sequence of a particulate siRNA binds to a complementary base sequence on a messenger RNA molecule transcribed from a specific gene. (guiding the enzyme into position.)
The enzyme then cuts the mRNA into smaller sections
The mRNA is no longer capable of being translated into a polypeptide
This gene has not been expressed, but rather blocked.
siRNA decreases gene expression
Q1. Transcriptional factors are important in the synthesis of particular proteins. describe how.
Bind to DNA;
Stimulate transcription
