Hormones AB

Question 1

What are the increased risks associated with oestrogen only HRT?

Answer 1

Increased risk of stroke and VTE

NOT CAD and breast cancer unlike E + P HRT

Question 2

What are the increased risks associated with combined oestrogen and progesterone HRT?

Answer 2

Increased risk of:

1. CAD
2. Stroke
3. VTE
4. Breast cancer

Question 3

What increased risks are seen in combined oestrogen and progesterone HRT? compared with oestrogen alone?

Answer 3

CAD

Breast cancer

Question 4

What are the decreased risks associated with oestrogen only HRT?

Answer 4

Decreased fracture risk

NOT decreased risk of CRC

Question 5

What are the decreased risks associated with combined oestrogen and progesterone HRT?

Answer 5

Decreased fracture risk AND colorectal cancer

Question 6

What are the proven positive effects of testosterone replacement? (3)

Answer 6

1. Improved libido (erections only in younger if TT

Question 7

What are the adverse effects of testosterone replacement? (3)

Answer 7

1. Erythrocytosis - most frequent
2. Worsen symptoms in severe BPH
3. Worsen untreated OSA

Note - effect on CVS unclear (conflicting evidence) and no relation to prostate cancer risk