Hormones

Question 1

aldosterone increases Na+ _________ where?

Answer 1

absorption

1. distal convoluted tubule
2. collecting duct

Question 2

ANP _____ Na+ reabsorption

Answer 2

decreases

Question 3

R-A system is stimulated by what? what is its response?

Answer 3

decrease in ECFV

increase in Na+ reabsorption

Question 4

what hormone keeps P-Na constant?

Answer 4

AVP

Question 5

neural strech receptors signal what hormones to regulate Na+?

Answer 5

AVP

Question 6

atrial stretch receptors signal what hormones to regulate Na+?

Answer 6

AVP

ANP

Question 7

atrial baroreceptors signal what hormone to regulate Na+?

Answer 7

AVP

Question 8

duh moment: what is the difference between AVP/vasopressin and ADH?

Answer 8

nothing, silly. they are the same thing.

Question 9

where does AVP work?

Answer 9

at NK2C channel in TA-LoH

Question 10

what stimulates aldosterone secretion?

Answer 10

plasma K

angiotensin

Question 11

what inhibits aldosterone?

Answer 11

plasma Na

Question 12

what are the ways aldosterone increases Na+ reab? hint: 4 ways

Answer 12

1. open Na channel in apical DCT, CD
2. Na/Cl co-transporter
3. synth of Na/K ATPase
4. synth of ATP via Krebs Cycle for Na/K ATPase

Question 13

is the affect of aldosterone on Na slow or fast?

Answer 13

slow

Question 14

natriuretic peptide is also called

Answer 14

ANP, ANF, or ANH

Question 15

what is the source of ANP? what stimulates secretion?

Answer 15

cardiac atria cells

when P-Na increases // direct stimulant is atrial distension

Question 16

what are the two targets of ANP?

Answer 16

renal tubular segments

renal blood vessels

Question 17

how does ANP decrease Na reab? three ways, note the location.

Answer 17

@ tubule: inhibits Na reab
@ renal vessel: increases GFR :: inc Na excretion
@ adrenal cortex: inhibits aldosterone and renin secretion

Question 18

what 2 hormones does ANP inhibit?

Answer 18

aldosterone

renin

Question 19

how does ANP inhibit Na reab @ tubule?

Answer 19

by Na channel p’lation

Question 20

what makes AI?

Answer 20

JG cells

Question 21

what makes angioten converting enz?

Answer 21

lung

kidney

Question 22

what does angioten converting enz do?

Answer 22

AI –> AII

Question 23

what does renin do?

Answer 23

apha2-globin —> AI

Question 24

what are the two functions of AII?

Answer 24

1. stimulate aldosterone production

2. stimulate Na reab in proximal tubule

Question 25

what produces aldosterone? what is the stimulus?

Answer 25

adrenal cortex

AII

Question 26

where does AII work?

Answer 26

the Na/H exchangers in the proximal tubule

Question 27

where does aldosterone work?

Answer 27

Na channel in DCT and CD

Question 28

what stimulates renin release?

Answer 28

low Cl- at JGA