Homework 1 Flashcards
1
Q
PD-1 blockers
A
pembrolizumab (Keytruda)
Nivolumab
Cemiplimab (Libtayo)
2
Q
PD-L1 blockers
A
atezolizumab (Tecentriq)
aveluman (Bavencio)
durvalumab (Imfinzi)
3
Q
BRAC1 drugs
A
olaparib
niraparib
talazoparib
rucaparib
(paribs)
4
Q
KRAS drugs
A
hinimetinib
trametinib
cobimetinib
(Tinibs)
5
Q
KRAS G12C inhibitor
A
AMG 510
6
Q
CDK4/CDK6 inhibitors
A
palbociclib
ribociclib
abemaciclib
(ciclibs)
7
Q
which KRAS mutation are the metinibs targeting?
A
PI3K
AKT
PDK1
8
Q
CTLA-4 inhibitor
A
ipilimumab
9
Q
most effective combo treatment
A
ribociclib 200
binimetinib 45
10
Q
DNA chip
A
only known mutations
high throughput
11
Q
Sanger sequencing
A
known and unknown
low throughput
expensive per BP
12
Q
next generation
A
whole exome
high throughout
known and unknown
cheap per base but expensive overall
13
Q
AMG 510 targets what
A
KRASG12C
